Search Results - aniruddha+kaushik

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Simultaneous Droplet-based Genotyping and mRNA Capture of Single Cells

Unmet Need / Invention Novelty: Single cell RNA transcriptomics has become an important technology in research and diagnostics but can be improved by incorporating genomic readouts from the same cells whose transcriptomes are being analyzed. Sequencing both genomic DNA and messenger RNA from a single cell is crucial for associating a cell’s genotype...

Published: 6/28/2024 | Inventor(s): Donald Zack, Claire Bell, Tza-Huei Wang, Aniruddha Kaushik, Pengfei Zhang

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays

Quantitative Measurements of 16S rRNA from Single Bacterial Cells for Accelerated Pathogen Identification and Antimicrobial Susceptibility Testing

Unmet needUrinary tract infection (UTI) is one of the most common infectious diseases in the world, affecting 50-60% of women at least once in their lifetime. In the United States, UTIs account for over 2 million emergency department visits and approximately $3.5 billion in healthcare costs annually. Unfortunately, UTI resistance to first line antibiotics...

Published: 6/28/2024 | Inventor(s): Tza-Huei Wang, Aniruddha Kaushik, Kuangwen Hsieh

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases > Antimicrobial Resistance

Impedance Based Feedback Control of Microfluidic Valves

Unmet NeedDroplet microfluidics is a growing field due to its potential to create high throughput assays while reducing reagent consumption in the process. The technology creates small droplets within fluid channels to generate biological assays. Frequently, these assays require an injection step so as to merge a reagent with the droplet at the correct...

Published: 6/27/2024 | Inventor(s): Tza-Huei Wang, Brant Axt, Yi-Fan Hsieh, Kuangwen Hsieh, Helena Zec, Aniruddha Kaushik, Yue Yun

Keywords(s): Computer and Network Systems, Computer Software, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools

Multiplexed, Continuous-Flow, Droplet-Based Platform for High-Throughput Genetic Detection

Unmet NeedMaintaining levels of crop production has become increasingly critical amidst growing populations and other emerging challenges for the $300 billion global crop market. Traditional crossbreeding of plants for desirable phenotypic traits is being improved by genetic marker assisted selection (MAS), where known genetic markers associated with...

Published: 6/27/2024 | Inventor(s): Tza-Huei Wang, Kuangwen Hsieh, Helena Zec, Lingshu Liu, Aniruddha Kaushik, Yue Yun

Keywords(s): Assay, Clinical Diagnostics, Crop Management, In Vitro Diagnostics, Microfluidic, Operations Management

Category(s): Technology Classifications > Industrial Tech > Agriculture, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Diagnostics, Technology Classifications > Industrial Tech, Technology Classifications > Research Tools, Technology Classifications > Engineering Tech > Agriculture

High-throughput microfluidic platform for high-density immobilization and parallelized quantitative real-time measurements of droplets

Unmet Need:Droplet platforms, which compartmentalize samples into encapsulated droplets for high-throughput analysis, have been used to detect and analyze diverse molecules, including nucleic acids, proteins, and single cells, at a higher sensitivity than traditional methods. Despite advantages in sensitivity and throughput, most existing droplet analysis...

Published: 6/28/2024 | Inventor(s): Tza-Huei Wang, Christine O'Keefe, Aniruddha Kaushik

Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics (Old), In Vitro Research Tool, Microfluidic, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays