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Digital High Resolution Melt Microfluidic Platform and Assay for Assessing Locus-specific Molecular Heterogeneity of DNA Methylation

Value Proposition· Simple, low-cost microfluidic tool that evaluates DNA methylation using non-invasive liquid biopsy samples. · Allows for sensitive, specific evaluation of epigenetic biomarkers for early detection of cancer. · Includes software and algorithms for improved diagnostic interpretation of DNA methylation analyses. Unmet...

Published: 3/14/2025 | Inventor(s): Tza-Huei Wang, Christine O'Keefe, Thomas Pisanic

Keywords(s):

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Blood & Tissue Samples

High-throughput microfluidic platform for high-density immobilization and parallelized quantitative real-time measurements of droplets

Unmet Need:Droplet platforms, which compartmentalize samples into encapsulated droplets for high-throughput analysis, have been used to detect and analyze diverse molecules, including nucleic acids, proteins, and single cells, at a higher sensitivity than traditional methods. Despite advantages in sensitivity and throughput, most existing droplet analysis...

Published: 3/14/2025 | Inventor(s): Tza-Huei Wang, Christine O'Keefe, Aniruddha Kaushik

Keywords(s): Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics (Old), In Vitro Research Tool, Microfluidic, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Research Tools > Assays