Search Results - lingshu+liu

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Local Sustained-release Nanocrystal Formulations to Treat and Prevent GI Fibrosis

Unmet Need: Gastrointestinal (GI) fibrosis, the accumulation of scar tissue in the intestinal wall as a complication in common GI autoimmune diseases such as ulcerative colitis (UC) and Crohn’s disease (CD), leads to intestinal strictures, abdominal pain, and reduced intestinal motility. Current pharmacological and surgical treatment methods have significant...

Published: 6/28/2024 | Inventor(s): Laura Ensign-Hodges, Florin Selaru, Min Kyung Joo, Rachel Shapiro, Ling Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Gastroenterology

New use of Sulconazole to Treat and Prevent GI Fibrosis

Published: 6/28/2024 | Inventor(s): Florin Selaru, Laura Ensign-Hodges, Ling Li, Min Kyung Joo

Keywords(s):

Category(s): Clinical and Disease Specializations > Gastroenterology

Locoregional Chemotherapy for Liver Cancers

Unmet NeedOver 800,000 people are diagnosed with liver cancer annually. As the leading cause of cancer death worldwide, liver cancer accounts for more than 700,000 deaths annually. Recently, Johns Hopkins researchers have developed new chemotherapeutic drugs to treat liver cancer that demonstrate higher efficacy than the current standard of care for...

Published: 6/27/2024 | Inventor(s): Florin Selaru, Ling Li

Keywords(s): Antagonists/Inhibitors, Cancers, Disease Indication, Drug Delivery Mechanism, Liver Cancer, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Repurposed Drugs, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Oncology > Liver Cancer

Liver-directed gene delivery via endoscopic retrograde cholangiopoancreatograpy (ERCP) directed hydrodynamic injection

Unmet NeedGene therapies are regarded as a potential revolution in the health sciences and pharmaceutical fields. The number of gene therapy trials has been steadily increasing in the United States, with around 170 trials taking place in 2015. All of these trials aim to treat the causes of different diseases instead of only relieving symptoms. Many...

Published: 6/27/2024 | Inventor(s): Florin Selaru, Vivek Kumbhari, Ling Li

Keywords(s): Drug Delivery Mechanism, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Multiplexed, Continuous-Flow, Droplet-Based Platform for High-Throughput Genetic Detection

Unmet NeedMaintaining levels of crop production has become increasingly critical amidst growing populations and other emerging challenges for the $300 billion global crop market. Traditional crossbreeding of plants for desirable phenotypic traits is being improved by genetic marker assisted selection (MAS), where known genetic markers associated with...

Published: 6/27/2024 | Inventor(s): Tza-Huei Wang, Kuangwen Hsieh, Helena Zec, Lingshu Liu, Aniruddha Kaushik, Yue Yun

Keywords(s): Assay, Clinical Diagnostics, Crop Management, In Vitro Diagnostics, Microfluidic, Operations Management

Category(s): Technology Classifications > Industrial Tech > Agriculture, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Microfluidics, Technology Classifications > Diagnostics, Technology Classifications > Industrial Tech, Technology Classifications > Research Tools, Technology Classifications > Engineering Tech > Agriculture

Mini-cancers Utilization as Decision Tools for Personalized Cancer Drug Regimens

The present invention includes methods for identifying chemotherapy treatments specifically suited for each cancer patient. The methods include obtaining a biopsy from the cancer patient; establishing a cancer culture from the biopsy; mixing the cancer culture with a matrix forming mini cancers. The mini cancers are then used to screen chemotherapy...

Published: 6/27/2024 | Inventor(s): Florin Selaru, Ling Li

Keywords(s): Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Research Instrument, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Companion Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

A computational approach for generating representative hepatitis C virus genomic sequences

C11517: Novel Synthetic Genomic Reconstruct for HCV TherapeuticsNovelty: This technology is an optimized synthetic reconstruct of genotype 1a hepatitis C virus (HCV) that is representative of globally-circulating strains of HCVValue Proposition: The reconstructed HCV genotype 1a virus is highly functional without adaptive mutations, which allows it...

Published: 6/27/2024 | Inventor(s): Supriya Munshaw, Lin Liu, Stuart Ray

Keywords(s): Computational Modeling Tool, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Discovery/Research Tools, Disease Indication, Hepatitis C Virus (HCV), In Silico Research Tool, Infectious Diseases, Physics

Category(s): Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus (HCV), Technology Classifications > Research Tools

A p105-based NF-(kappa) B Super repressor

C04290: A p105-based NF-(kappa) B Super repressor Technical Details: Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is latent, and is activated transiently by stimuli and stresses. However, under pathological...

Published: 6/27/2024 | Inventor(s): Li Lin

Keywords(s): Biologics, Cancers, Chemotherapy, Disease Indication, Nucleic Acid, Single, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities