Search Results - john+laterra

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Value PropositionFirst-in-Class Targeting of a Novel Oncogenic Ion Channel: Inhibiting KCNK9 represents a new therapeutic modality in cancers where traditional approachesTumor-Specific Overexpression Enables Selectivity: KCNK9 is overexpressed in various tumors (e.g., breast, gastric, lung) but has limited expression in most normal tissuesPro-Apoptotic...

Published: 6/27/2025 | Inventor(s): John Laterra, Amy Fulton

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Lung Cancer, Clinical and Disease Specializations > Oncology > Gastric Cancer, Technology Classifications > Therapeutic Modalities > Antibodies

Novel monoclonal antibody inhibitors targeting potassium channel KCNK9

Unmet Need:KCNK9 is one of 15 mammalian subtypes in the highly conserved family of two-pore domain potassium channels (K2P). Under physiological conditions, KCNK9 is primarily expressed in the brain where it serves to maintain cellular membrane potentials. However, overexpression of KCNK9 has been detected in breast, lung, skin, and other cancers, and...

Published: 6/26/2025 | Inventor(s): John Laterra, Han Sun, Min Li, Amy Fulton

Keywords(s): Antibodies, Biologics, Breast Cancer, Cancers, Disease Indication, Lung Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Lung Cancer

Method for highly efficient conversion of human stem cells to lineage-specific neurons.

Conversion of human stem cells to dopaminergic neurons using a single, high-efficiency factor JHU REF: [C12596] Invention novelty: To convert human stem cells into dopaminergic neurons at high efficiency. Value Proposition As many as one million Americans suffer from Parkinson's disease (Parkinson’s Disease Foundation, 2012). Cell...

Published: 6/26/2025 | Inventor(s): John Laterra, Mingyao Ying

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Clinical Diagnostics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Diagnostics, In Vitro Research Tool, Sample Prep Method, Stem Cells, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Diagnostics > Biomarkers

Highly Efficient Conversion of Human Stem Cells to Dopaminergic Neurons by Proneural Transcription Factor Atoh1

C11838: Novel Method to Convert Human Stem Cells into Dopaminergic NeuronsNovelty: This technology is a novel approach to induce and drive a highly efficient conversion of human neural stem cells (NSCs) into dopaminergic (DA) neurons.Value Proposition: Cell replacement therapy is a potential strategy to counter progressive neurological diseases, such...

Published: 6/26/2025 | Inventor(s): Mingyao Ying, John Laterra

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Stem Cells, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology