Search Results - mingyao+ying

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Method for highly efficient conversion of human stem cells to lineage-specific neurons.

Conversion of human stem cells to dopaminergic neurons using a single, high-efficiency factor JHU REF: [C12596] Invention novelty: To convert human stem cells into dopaminergic neurons at high efficiency. Value Proposition As many as one million Americans suffer from Parkinson's disease (Parkinson’s Disease Foundation, 2012). Cell...

Published: 6/27/2024 | Inventor(s): John Laterra, Mingyao Ying

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Clinical Diagnostics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Diagnostics, In Vitro Research Tool, Sample Prep Method, Stem Cells, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Diagnostics > Biomarkers

Highly Efficient Conversion of Human Stem Cells to Dopaminergic Neurons by Proneural Transcription Factor Atoh1

C11838: Novel Method to Convert Human Stem Cells into Dopaminergic NeuronsNovelty: This technology is a novel approach to induce and drive a highly efficient conversion of human neural stem cells (NSCs) into dopaminergic (DA) neurons.Value Proposition: Cell replacement therapy is a potential strategy to counter progressive neurological diseases, such...

Published: 6/27/2024 | Inventor(s): Mingyao Ying, John Laterra

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Stem Cells, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology

Conditional Alpha Synuclein Transgenic Mice

C10840: Conditional Alpha Synuclein Transgenic MiceValue Proposition: JHU Inventors have developed conditional alpha-synuclein transgenic mice that can express A53T, E46K or C-terminally truncated alpha-synuclein. ADVANTAGES - Effects of different pathological variants of the alpha-synuclein protein can be directly compared in the ROSA26-alphaSyn mice...

Published: 6/27/2024 | Inventor(s): Valina Dawson, Mingyao Ying, Darren Moore, Ted Dawson

Keywords(s): CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Parkinson's Disease, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools