Search Results - darren+moore

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Conditional Alpha Synuclein Transgenic Mice

C10840: Conditional Alpha Synuclein Transgenic MiceValue Proposition: JHU Inventors have developed conditional alpha-synuclein transgenic mice that can express A53T, E46K or C-terminally truncated alpha-synuclein. ADVANTAGES - Effects of different pathological variants of the alpha-synuclein protein can be directly compared in the ROSA26-alphaSyn mice...

Published: 7/4/2024 | Inventor(s): Valina Dawson, Mingyao Ying, Darren Moore, Ted Dawson

Keywords(s): CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Parkinson's Disease, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Phosphospecific LRRK2 Antibodies to Monitor Activation State of LRRK2

C10751: Phosphospecific LRRK2 Antibodies to Monitor Activation State of LRRK2Value Proposition: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are responsible for late-onset autosomal dominant Parkinson's disease (PD). LRRK2 may have roles in pathogenesis of several neurodegenerative disorders. Inventors have produced antibodies that can...

Published: 7/4/2024 | Inventor(s): Darren Moore, Xiaojie Li, Valina Dawson, Ted Dawson

Keywords(s): Antibodies, Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Parkinson's Disease, Polyclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Generation of Leucine-rich Repeat Kinase 2 (LRRK2) Wild-type, G2019S and R1441C Transgenic Mice

C10386: Generation of Leucine-rich Repeat Kinase 2 (LRRK2) Wild-type and mutant LRRK2 Transgenic MiceValue Proposition: Mutations in the Leucine-rich Repeat Kinase 2 (LRRK2) gene are a common cause of late-onset familial Parkinson's disease (PD) and mutations in LRRK2 are also associated with sporadic Parkinson's disease. These LRRK2 transgenic mice...

Published: 7/4/2024 | Inventor(s): Ted Dawson, Darren Moore, Valina Dawson

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Neurodegenerative Diseases, Parkinson's Disease