Search Results - xiaojie+li

4 Results

Sort By:

Single-Molecule Analysis by Shape (SMASH) as an Ultra-sensitive Blood Test for Cancer Biomarkers

Unmet Need / Invention Novelty: Early cancer detection leads to increased survival rates in patients. However, current biomarker assays to detect circulating tumor DNA and proteins lack the sensitivity needed to detect the earliest stages of cancer development.Technical Details: Johns Hopkins researchers have developed a novel assay to detect circulating...

Published: 7/5/2024 | Inventor(s): Chien-Fu Hung, Chih-Ping Mao, Shih-Chin Wang, Jie Xiao, T.c. Wu

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old)

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > In Vitro Diagnostics

Early Cancer Detection by Single-molecule Imaging of Nucleocytoplasmic Tumor-specific Proteins in the Peripheral Circulation

Unmet Need / Invention Novelty: Due to lack of effective early detection modalities, ovarian and pancreatic cancers are rarely found until the disease has progressed and hence are highly lethal. To overcome these limitations we report an ultra-sensitive microfluidic chip designed to bind and digitally quantify tumor-derived cancer proteins for an early...

Published: 7/4/2024 | Inventor(s): T.c. Wu, Chih-Ping Mao, Shih-Chin Wang, Jie Xiao, Chien-Fu Hung

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Research Instrument

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Co-translational activation of a transcription factor by proteolytic cleavage

C11384: Novel Method for Real Time Monitoring of Gene ExpressionNovelty: The invention is a novel method which allows the targeted activation and characterization of a protein molecule of interest in a living cell without disrupting its natural state or functionality.Value Proposition: Currently, protein expression can be followed using translation...

Published: 7/4/2024 | Inventor(s): Jie Xiao, Zachary Hensel

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Enzymes, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Phosphospecific LRRK2 Antibodies to Monitor Activation State of LRRK2

C10751: Phosphospecific LRRK2 Antibodies to Monitor Activation State of LRRK2Value Proposition: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are responsible for late-onset autosomal dominant Parkinson's disease (PD). LRRK2 may have roles in pathogenesis of several neurodegenerative disorders. Inventors have produced antibodies that can...

Published: 7/4/2024 | Inventor(s): Darren Moore, Xiaojie Li, Valina Dawson, Ted Dawson

Keywords(s): Antibodies, Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Parkinson's Disease, Polyclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Antibodies, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools