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A method to enhance delivery and editing efficiencies of CRISPR-Cas9

Value Proposition· Mechanical tuning of stiffness and viscoelasticity results in higher editing efficiency and requires less transfection reagents compared to traditional plasmid-based CRISPR-Cas9 methods. · Enhanced cell-substrate interactions between the cells and gels leads to greater uptake of nanoparticles, quicker onset of gene editing,...

Published: 10/4/2024 | Inventor(s): Luo Gu, Joon Eoh

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Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Research Tools

Computational method for the 3D reconstruction and multi-labelling of serially sectioned tissue

Unmet Need / Invention Novelty: Three-dimensional (3D) tissue reconstruction permits analyses of the relationships between cellular factors, tissue structure, and diseasepathology.Current methods used to visualize and quantify tissue structures in 3D space are limited to small volumes and have various constraints relating to consistency, information...

Published: 10/4/2024 | Inventor(s): Denis Wirtz, Ashley Kiemen, Pei-Hsun Wu, Ralph Hruban, Laura Wood, Alexandra Sneider, Luo Gu, Mehran Habibi, Joo Ho Kim

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Category(s): Technology Classifications > Research Tools