Search Results - psychiatric+diseases

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A DNA methylation and genotype specific biomarker of suicide attempt

Novel Biomarkers for Predicting Suicide RiskJHU REF: [C12394]Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting suicide risk. Value Proposition: Almost 30,000 people die of suicide each year in the United States, and 1 million people die worldwide. In the teenage population, it is the second leading cause of...

Published: 3/13/2025 | Inventor(s): Holly Wilcox, Zachary Kaminsky

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Epigenetic, In Vitro Diagnostics, In Vitro Diagnostics (Old), Methylation, Prognostic Biomarker, Psychiatric Diseases, Suicidal Impulses, Suicide/Suicidal Impulses

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Clinical and Disease Specializations > Psychiatry > Suicidal Impulses

DNA Methylation Biomarkers of Post Partum Depression Risk

Invention Novelty: This invention provides DNA methylation-based biomarkers for predicting postpartum depression (PPD) risk . Value Proposition: PPD occurs in approximately 10-15% of women and represents a serious health risk to both mothers and their offspring. Increased depression risk in pregnant women is not predicted by hormonal fluctuations. This...

Published: 3/13/2025 | Inventor(s): Zachary Kaminsky, Jennifer Payne, Todd Gould

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Post Partum Depression, Postpartum Depression, Prognostic Biomarker, Psychiatric Diseases

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Clinical and Disease Specializations > Psychiatry > Postpartum Depression

Novel Therapeutic Target for Neural Regeneration, Stroke and Anti-depressants

Unmet needCurrent anti-depressants in the market have various limitations including lack of broad-spectrum drugs, unexpected side effects, toxicity and low efficacy for certain patients. New generation of anti-depressants based on most recent biomedical discoveries concerning depression are urgently needed. Technology overviewJohns Hopkins researchers...

Published: 3/13/2025 | Inventor(s): Dengke Ma, Guo-li Ming, Hongjun Song

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Mechanism of Action Biomarker, Psychiatric Diseases, Stroke, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Stroke, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Targets

C14346 - New, Simple and Quick Test to Diagnose, Predict, and Prevent Brain Disorders Using Non-invasive Nasal Brush and Single-Cell Analysis

Invention novelty: This technology is the first clinical assay to measure biological markers that reflect symptom severity and drug efficacy for mental disorders, such as depression and schizophrenia. This tool is useful for not only diagnosing such disorders, but also predicting them before onset, choosing the best treatments for individual patients,...

Published: 3/13/2025 | Inventor(s): Akira Sawa, Koko Ishizuka, Yeewen Wu, Youjin Chung, Nao Gamo

Keywords(s): Biopsy Tools, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Tool, Disease Indication, Psychiatric Diseases, Schizophrenia

Method to Determine Risk of Developing PTSD after Stressful Events

Unmet Need:Post-traumatic stress disorder (PTSD) is recognized by the Department of Defense, the Department of Veterans Affairs, and the National Institute of Mental Health as a major medical issue for both deployed and returning U.S. troops. PTSD rates in military personnel following deployment range from 5 to 15% (Sundin et al, 2010; Reijnen et al,...

Published: 3/13/2025 | Inventor(s): Zachary Kaminsky, Marco Boks

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, In Vitro Diagnostics, Post-Traumatic Stress Disorder, Post-Traumatic Stress Disorder (PTSD), Prognostic Biomarker, Psychiatric Diseases

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Post-Traumatic Stress Disorder, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry

Multiple Lines of Induced Pluripotent Stem Cells (iPSCs) Derived from Members of an American Family with, and without DISC1 Mutations Associated with Schizophrenia and Depression

Invention Novelty: These tangible materials are induced Pluripotent Stem Cells (iPSCs) derived from members with or without DISC1 (Disrupted in schizophrenia 1) mutations in an American family associated with schizophrenia. Value Proposition:Mutations in DISC1 have been shown to predispose individuals to the development of psychiatric illnesses such...

Published: 3/13/2025 | Inventor(s): Hongjun Song, Christopher Ross, Guo-li Ming, Russell Margolis

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Schizophrenia, Stem Cells, Target-based Screening Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools > Human Cell Lines

Homozygous Mutant DISC1 Mice, Lines 1001 and 1302

Homozygous Mutant DISCI MiceJHU REF: C11617 Invention Novelty: The disclosed technologies are two tangible materials that are improved homozygous mouse strains with inducible expression of mutant human Disrupted-In-Schizophrenia-1 (hDISC1) using Tet-off system under the control of CAMKII. Value Proposition: The disclosed materials are improved...

Published: 3/13/2025 | Inventor(s): Mikhail Pletnikov

Keywords(s): Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Psychiatric Diseases, Schizophrenia, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Targets

024414 B6129(SJL)-Grip1-tm1Rlh, 024415 B6.129S6(Cg)-Wwc1-tm1.1Rlh, 024417 B6.129S6(SJL)-Prkcz-tm1.1Rlh, 024418 B6.129S6-Gria1-tm7Rlh, 024419 B6.129(Cg)-Gria2-tm2Rlh, 024420 B6.129(Cg)-Gria1-tm4Rlh

TITLE: 024414 B6.129(SJL)-Grip1tm1Rlh 024415 B6.129S6(Cg)-Wwc1tm1.1Rlh024417 B6.129S6(SJL)-Prkcz tm1.1Rlh024418 B6.129S6-Gria1tm7Rlh 024419 B6.129(Cg)-Gria2tm2Rlh024420 B6.129(Cg)-Gria1tm4Rlh CASE NUMBER: C13635ABSTRACTInformation are from Jacksons Lab website (https://www.jax.org/mouse-search?searchTerm=Richard%20Huganir)Stock No. 024414 B6.129(SJL)-Grip1tm1Rlh...

Published: 3/13/2025 | Inventor(s): Richard Huganir

Keywords(s): CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Psychiatric Diseases, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

iPSCs from Schizophrenia patents with a DISC1 mutation

C11364: Schizophrenia Associated Induced Pluripotent Stem Cell LinesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from somatic cells from members of an American family with schizophrenia and without a schizophrenia diagnosisValue Proposition: Mutations in the Disrupted-in-Schizophrenia 1 (DISC1) gene have been shown to predispose individuals...

Published: 3/13/2025 | Inventor(s): Guo-li Ming, Christopher Ross, Russell Margolis, Hongjun Song

Keywords(s): Basic Research Biomarker, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Schizophrenia, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools

Novel Compounds targeting GAPDH-Siah Cell Death Cascade

Novel Compounds targeting GAPDH-Siah Cell Death Cascade JHU Ref #: C11114 Value Proposition Targeted therapy: Small molecule compound that inhibits the GAPDH-Siah cell cascade to prevent cell death in degenerative diseases Broad Application: Effective across stress-mediated conditions, including Alzheimer’s, Parkinson’s, stroke,...

Published: 3/13/2025 | Inventor(s): Neelam Shahani, Toshiaki Saito, David Kass, Eiki Takimoto, Akira Sawa

Keywords(s): Alzheimer's Disease, Antagonists/Inhibitors, Biomarker, CNS and Neurological Disorders, Disease Indication, Huntington's Disease, Mechanism of Action Biomarker, Neurodegenerative Diseases, Non-novel, Novel, Predicted Novelty, Psychiatric Diseases, Repurposed, Schizophrenia, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Parkinson’s Disease

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