Search Results - koko+ishizuka

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A CRISPR-based technology to treat cytomegalovirus (CMV) and other Viral Infections.

Value PropositionNovel Mechanism: Utilizes a Crispr/Cas9 system to target the viral genome to prevent production of the disease-causing protein 1E1.Widely Adaptable: Design allows modulation to fit a wide variety of other viral genomes to combat other infectious diseases.Therapeutic Potential: Administration of proposed technology to infected pregnant...

Published: 1/22/2026 | Inventor(s): Akira Sawa, Koko Ishizuka, Kazuhiro Ishii, Stephanie Tankou

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Cytomegalovirus, Technology Classifications > Therapeutic Modalities > Gene Therapies

Mechanistic insights reveal drug discovery target for lithium responders and non-responders

Value PropositionNew mouse model for mood switching behavior with viability for compound screeningDemonstrated that BK channels in excitatory neurons are involved in cellular pathology of patients by affecting Ca2+ kineticsApplication to both lithium responders and non-responders Unmet NeedBipolar disorder (BPD) has a lifetime prevalence of 4-5% in...

Published: 1/22/2026 | Inventor(s): Akira Sawa, Rupali Srivastava, Koko Ishizuka

Keywords(s):

Category(s): Clinical and Disease Specializations > Psychiatry > Bipolar Disorder, Clinical and Disease Specializations > Psychiatry > Mood Disorders, Clinical and Disease Specializations > Psychiatry > Suicidal Impulses, Technology Classifications > Research Tools > Animal Models

C14346 - New, Simple and Quick Test to Diagnose, Predict, and Prevent Brain Disorders Using Non-invasive Nasal Brush and Single-Cell Analysis

Invention novelty: This technology is the first clinical assay to measure biological markers that reflect symptom severity and drug efficacy for mental disorders, such as depression and schizophrenia. This tool is useful for not only diagnosing such disorders, but also predicting them before onset, choosing the best treatments for individual patients,...

Published: 1/22/2026 | Inventor(s): Akira Sawa, Koko Ishizuka, Yeewen Wu, Youjin Chung, Nao Gamo

Keywords(s): Biopsy Tools, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Tool, Disease Indication, Psychiatric Diseases, Schizophrenia

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry