Search Results - akira+sawa

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Mechanistic insights reveal drug discovery target for lithium responders and non-responders

Value PropositionNew mouse model for mood switching behavior with viability for compound screeningDemonstrated that BK channels in excitatory neurons are involved in cellular pathology of patients by affecting Ca2+ kineticsApplication to both lithium responders and non-responders Unmet NeedBipolar disorder (BPD) has a lifetime prevalence of 4-5% in...

Published: 3/14/2025 | Inventor(s): Akira Sawa, Rupali Srivastava, Koko Ishizuka

Keywords(s):

Category(s): Clinical and Disease Specializations > Psychiatry > Bipolar Disorder, Clinical and Disease Specializations > Psychiatry > Mood Disorders, Clinical and Disease Specializations > Psychiatry > Suicidal Impulses, Technology Classifications > Research Tools > Animal Models

C14346 - New, Simple and Quick Test to Diagnose, Predict, and Prevent Brain Disorders Using Non-invasive Nasal Brush and Single-Cell Analysis

Invention novelty: This technology is the first clinical assay to measure biological markers that reflect symptom severity and drug efficacy for mental disorders, such as depression and schizophrenia. This tool is useful for not only diagnosing such disorders, but also predicting them before onset, choosing the best treatments for individual patients,...

Published: 3/13/2025 | Inventor(s): Akira Sawa, Koko Ishizuka, Yeewen Wu, Youjin Chung, Nao Gamo

Keywords(s): Biopsy Tools, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Tool, Disease Indication, Psychiatric Diseases, Schizophrenia

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry

Novel Compounds targeting GAPDH-Siah Cell Death Cascade

Novel Compounds targeting GAPDH-Siah Cell Death Cascade JHU Ref #: C11114 Value Proposition Targeted therapy: Small molecule compound that inhibits the GAPDH-Siah cell cascade to prevent cell death in degenerative diseases Broad Application: Effective across stress-mediated conditions, including Alzheimer’s, Parkinson’s, stroke,...

Published: 3/13/2025 | Inventor(s): Neelam Shahani, Toshiaki Saito, David Kass, Eiki Takimoto, Akira Sawa

Keywords(s): Alzheimer's Disease, Antagonists/Inhibitors, Biomarker, CNS and Neurological Disorders, Disease Indication, Huntington's Disease, Mechanism of Action Biomarker, Neurodegenerative Diseases, Non-novel, Novel, Predicted Novelty, Psychiatric Diseases, Repurposed, Schizophrenia, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Parkinson’s Disease

Method and Kit for Diagnosis and Drug Screening Towards Psychiatric Disorders

C04397: Method and Kit for Diagnosis and Drug Screening Towards Psychiatric DisordersValue Proposition: Johns Hopkins University is currently seeking licensees for a novel diagnostic/prognostic technology. Schizophrenia is a devastating psychiatric disorder, characterized by disturbances of thought, emotion, and perception. Diagnosis is currently based...

Published: 3/13/2025 | Inventor(s): Akira Sawa

Keywords(s): Biomarker, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Psychiatric Diseases, Schizophrenia