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Novel Compounds targeting GAPDH-Siah Cell Death Cascade

Novel Compounds targeting GAPDH-Siah Cell Death Cascade JHU Ref #: C11114 Value Proposition Targeted therapy: Small molecule compound that inhibits the GAPDH-Siah cell cascade to prevent cell death in degenerative diseases Broad Application: Effective across stress-mediated conditions, including Alzheimer’s, Parkinson’s, stroke,...

Published: 3/13/2025 | Inventor(s): Neelam Shahani, Toshiaki Saito, David Kass, Eiki Takimoto, Akira Sawa

Keywords(s): Alzheimer's Disease, Antagonists/Inhibitors, Biomarker, CNS and Neurological Disorders, Disease Indication, Huntington's Disease, Mechanism of Action Biomarker, Neurodegenerative Diseases, Non-novel, Novel, Predicted Novelty, Psychiatric Diseases, Repurposed, Schizophrenia, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Parkinson’s Disease