Search Results - michael+mcmahon

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Novel CEST MRI-suitable Reporter Genes to Non-Invasively Monitor Distribution and Migration of Biotherapeutics

Unmet NeedGreen Fluorescent Protein (GFP) reporter genes and PET (positron-emission tomography) imagining are two techniques which have been widely used to monitor the movement and distribution of specific molecules in cells or animals. Imaging GFP-tagged molecules is often destructive to the sample and is limited by the degree that light can penetrate...

Published: 6/26/2025 | Inventor(s): Assaf Gilad, Michael Mcmahon, Paul Winnard, Venu Raman, Jeff Bulte, Peter van Zijl

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

Variants of Me-LOVARs

We claim a Multi-echo Parametric VARiation Saturation (MePaVARS) sequence, which places multiple image readouts in between a series of saturation pulses. with the saturation pulse parameters varied which allows the generation of CEST contrast maps with patterns of signal loss encoded into the images for better discrimination between various CEST imaging...

Published: 6/26/2025 | Inventor(s): Xiaolei Song, Michael Mcmahon

Keywords(s): Image Display Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Salicylic Acid-based Polymeric CEST Contrast Agents for Molecular Imaging of Prostate-specific Membrane Antigen

We have discovered that a salicylic acid (SA) analog when grafted on a polymeric platform is able to produce significantly enhanced contrast in MR images detectable through chemical exchange saturation transfer (CEST). That SA modified polymeric platform (SA PolyCEST), has been further modified with Glu-Lysine urea, an inhibitor of Prostate-specific...

Published: 6/26/2025 | Inventor(s): Xing Yang, Michael Mcmahon, Sangeeta Ray, Xiaolei Song, Martin Pomper

Keywords(s): Cancers, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

Sialicylic Acid -Conjugated Dendrimers as a Tunable, High-Performance CEST MRI NanoPlatform for Diagnostic Imaging

Value Proposition: Brain tumors have poor survival rates and treatment options are limited due to the requirement of therapeutics to cross the blood-brain-barrier to reach the tumor site. Convection-enhanced delivery (CED) of nanoformulations is gaining increasing attention to overcome this challenge. However, there is an unmet need for imaging modalities...

Published: 6/26/2025 | Inventor(s): Wojciech Lesniak, Michael Mcmahon, Sridhar Nimmagadda, Nikita Oskolkov, Xiaolei Song, Martin Pomper

Keywords(s): Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

A Surface Conjugation Approach to Formulate Nano-carriers for Magnetic Resonance Imaging (MRI) Tracking

Nanoparticle Diagnostic and Therapeutic ImagingJHU REF: [C12327]Invention novelty: Improved method for magnetic resonance imaging of diagnostic and therapeutic nano-carriers.Value PropositionThere is an urgent need to develop simple and safe approaches to image nano-carriers in vivo over the course of treatment, which allows physicians to monitor the...

Published: 6/26/2025 | Inventor(s): Justin Hanes, Himatkumar Patel, Michael Mcmahon, Kannie Chan, Nikita Oskolkov, Tao Yu

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

Non-invasive Sensing of Free Metal Ions Using iCEST

C12425: MRI-based Non-Invasive Metal Ion Detection SystemNovelty: Novel method combining chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) with 19F fluorinated chelators to detect free metal ions with high sensitivity and specificity.Value Proposition: Although metal ions are involved in a myriad of biological processes,...

Published: 6/26/2025 | Inventor(s): Michael Mcmahon, Jeff Bulte, Amnon Bar-Shir

Keywords(s): Chemical particulates, Environmental Sensing, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Integrated Sensing System, Magnetic Resonance Imaging (MRI), Sensing Modality

Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Industrial Tech, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Engineering Tech > Energy, Infrastructure & Environment

CEST Substrates

C12412: New Reporter System for CEST MRINovelty: Novel reporter system for chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) without paramagnetic metal substrates.Value Proposition: Among the clinically applied 3D imaging modalities, MRI has the highest resolution and is therefore the preferred method for detection of cellular...

Published: 6/26/2025 | Inventor(s): Jeff Bulte, Guanshu Liu, Raag Airan, Michael Mcmahon, Peter van Zijl, Amnon Bar-Shir, Assaf Gilad

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Technology Classifications > Computers, Electronics & Software > Sensors

Azole Heterocycles for MRI Contrast and pH Sensing

C12402: Novel Class of Organic MRI Contrast AgentsNovelty: Group of organic compounds as magnetic resonance imaging (MRI) contrast agents for detecting pH changes in vivo.Value Proposition: The most commonly used MRI contrast agents contain the metal gadolinium which been associated with Nephrogenic Systemic Fibrosis. Therefore, organic agents serve...

Published: 6/26/2025 | Inventor(s): Sangeeta Ray, Martin Pomper, Xing Yang, Xiaolei Song, Michael Mcmahon

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

Salicylic Acid and Its Analogs for MRI Contrast

C12400: Salicylic Acid and its Analogs as MRI Contrast AgentsNovelty: New use of salicylic acid and its analogues as improved contrast agents for magnetic resonance imaging (MRI).Value Proposition: Currently used MRI contrast agents either have toxic effects or have certain sensitivity drawbacks, especially due to a small chemical shift difference between...

Published: 6/26/2025 | Inventor(s): Sangeeta Ray, Xing Yang, Martin Pomper, Xiaolei Song, Michael Mcmahon

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Non-novel, Predicted Novelty, Repurposed

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics > Diagnostic Imaging

Novel Peptide Hydrogels Generating Chemical Exchange Saturation Transfer MRI Contrast and Uses Thereof

C12189: Novel Self-Assembling Peptide Hydrogels for MRINovelty: Self-assembling peptide hydrogels that can function as non-metallic MRI contrast agents.Value Proposition: Currently used metallic or non-metallic MRI contrast agents have some limitations for in vivo imaging such as toxicity or difficulties in distinguishing the contrast from other sources...

Published: 6/26/2025 | Inventor(s): Nikita Oskolkov, Xiaolei Song, Michael Giano, Joel Schneider, Kannie Chan, Michael Mcmahon

Keywords(s): Drug Delivery Vehicle, Hydrogel, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

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