Search Results - xiaolei+song

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Variants of Me-LOVARs

We claim a Multi-echo Parametric VARiation Saturation (MePaVARS) sequence, which places multiple image readouts in between a series of saturation pulses. with the saturation pulse parameters varied which allows the generation of CEST contrast maps with patterns of signal loss encoded into the images for better discrimination between various CEST imaging...

Published: 6/27/2024 | Inventor(s): Xiaolei Song, Michael Mcmahon

Keywords(s): Image Display Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Salicylic Acid-based Polymeric CEST Contrast Agents for Molecular Imaging of Prostate-specific Membrane Antigen

We have discovered that a salicylic acid (SA) analog when grafted on a polymeric platform is able to produce significantly enhanced contrast in MR images detectable through chemical exchange saturation transfer (CEST). That SA modified polymeric platform (SA PolyCEST), has been further modified with Glu-Lysine urea, an inhibitor of Prostate-specific...

Published: 6/27/2024 | Inventor(s): Xing Yang, Michael Mcmahon, Sangeeta Ray, Xiaolei Song, Martin Pomper

Keywords(s): Cancers, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

Sialicylic Acid -Conjugated Dendrimers as a Tunable, High-Performance CEST MRI NanoPlatform for Diagnostic Imaging

Value Proposition: Brain tumors have poor survival rates and treatment options are limited due to the requirement of therapeutics to cross the blood-brain-barrier to reach the tumor site. Convection-enhanced delivery (CED) of nanoformulations is gaining increasing attention to overcome this challenge. However, there is an unmet need for imaging modalities...

Published: 6/27/2024 | Inventor(s): Wojciech Lesniak, Michael Mcmahon, Sridhar Nimmagadda, Nikita Oskolkov, Xiaolei Song, Martin Pomper

Keywords(s): Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

Azole Heterocycles for MRI Contrast and pH Sensing

C12402: Novel Class of Organic MRI Contrast AgentsNovelty: Group of organic compounds as magnetic resonance imaging (MRI) contrast agents for detecting pH changes in vivo.Value Proposition: The most commonly used MRI contrast agents contain the metal gadolinium which been associated with Nephrogenic Systemic Fibrosis. Therefore, organic agents serve...

Published: 6/27/2024 | Inventor(s): Sangeeta Ray, Martin Pomper, Xing Yang, Xiaolei Song, Michael Mcmahon

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

Salicylic Acid and Its Analogs for MRI Contrast

C12400: Salicylic Acid and its Analogs as MRI Contrast AgentsNovelty: New use of salicylic acid and its analogues as improved contrast agents for magnetic resonance imaging (MRI).Value Proposition: Currently used MRI contrast agents either have toxic effects or have certain sensitivity drawbacks, especially due to a small chemical shift difference between...

Published: 6/27/2024 | Inventor(s): Sangeeta Ray, Xing Yang, Martin Pomper, Xiaolei Song, Michael Mcmahon

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Non-novel, Predicted Novelty, Repurposed

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics > Diagnostic Imaging

Novel Peptide Hydrogels Generating Chemical Exchange Saturation Transfer MRI Contrast and Uses Thereof

C12189: Novel Self-Assembling Peptide Hydrogels for MRINovelty: Self-assembling peptide hydrogels that can function as non-metallic MRI contrast agents.Value Proposition: Currently used metallic or non-metallic MRI contrast agents have some limitations for in vivo imaging such as toxicity or difficulties in distinguishing the contrast from other sources...

Published: 6/27/2024 | Inventor(s): Nikita Oskolkov, Xiaolei Song, Michael Giano, Joel Schneider, Kannie Chan, Michael Mcmahon

Keywords(s): Drug Delivery Vehicle, Hydrogel, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

A Multi-echo Length and Offset VARied Saturation (Me-LOVARS) Method for Chemical Exchange Saturation Transfer (CEST) MR Imaging

C12185: High Temporal Resolution CEST ImagingNovelty: This invention allows for a higher temporal resolution for Chemical Exchange Saturation Transfer (CEST) imaging while preserving high contrast ratios.Value Proposition: CEST imaging allows for the detection of low concentrations of solutes. However, in order to do this type of imaging, a long saturation...

Published: 6/27/2024 | Inventor(s): Jiadi Xu, Michael Mcmahon, Xiaolei Song

Keywords(s): Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Length (and Offset) VARied Saturation (LOVARS) Method for Chemical Exchange Saturation Transfer (CEST) MRI

C11505: Method for Obtaining Multi-probe Magnetic Resonance Images (MRI)Novelty: A novel method of obtaining simultaneous detection of multiple probes within an MRI, allowing for a visual representation of the data that can be separated based on probes.Value Proposition: Current MRI technology would significantly benefit from having the ability to discriminate...

Published: 6/27/2024 | Inventor(s): Jeff Bulte, Assaf Gilad, Michael Mcmahon, Xiaolei Song

Keywords(s): Cancers, Disease Indication, Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices