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New fluorinated DREADD actuators and ligands suitable for PET imaging

Unmet NeedChemogenetics is defined as a method by which proteins are made to interact with small molecules, typically neurological molecules, as they have never been interacted with before. There is a powerful and versatile approach for remote and momentary manipulation of cellular activity called Designer Receptors Exclusively Activated by Designer...

Published: 3/14/2025 | Inventor(s): Andrew Horti, Martin Pomper, Michael Michaelides, Jordi Bonaventura, Feng Hu, Juan Luis Gomez, Marta Sanchez-Soto

Keywords(s): Biologics, Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Labels/Markers, Radioisotope Therapy, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors