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Anastasis Biosensor CaspaseTracker rtTA – C15014 Unmet NeedAnastasis, Greek for "rising to life", is a newly discovered cell recovery phenomenon by which a cell undergoes reversal of apoptosis or programmed cell death. Research has shown that even cells that exhibit the hallmarks of late-stage cell death such as activation of executioner caspases...

Published: 9/26/2024 | Inventor(s): Ho Lam Tang, Ho Man Holly Tang

Keywords(s): Animal Imaging Tools, apoptosis, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vitro Diagnostics, In Vivo Medical Imaging, In Vivo Research Tool, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers

C14439: Anastasis Biosensor (Split version)

INVENTION NOVELTYThis technology involves a biosensor that is able to label and track cells in vitro and in vivo that have reversed apoptosis (Anastasis, Greek for “rising to life”) after they experienced mitochondrial outer membrane permeabilization (MOMP) and caspase-3 activation, the 2 most recognized hallmarks of apoptosis at execution stage. This...

Published: 9/26/2024 | Inventor(s): Ho Lam Tang, Ho Man Holly Tang

Keywords(s): Cancers, Clinical Diagnostics, Diagnostic Tool, Disease Indication

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics

C11872: Novel Method to Visualize Cells that Undergo Apoptosis Reversal

Value Proposition: This biosensor may be used to identify anastasis events in animals or cells, in screens to identify genes/protein/RNAs that modulate anastasis or in screens for small molecules that potentiate or inhibit anastasis. Technology advantages: - This biosensor can be used to label cells in vivo or in vitro. - This technology permanently...

Published: 9/26/2024 | Inventor(s): Ho Lam Tang, Denise Montell

Keywords(s): Discovery/Research Tools, Fly Model, Imaging and Sensing Systems, In Vitro Research Tool, In Vivo Medical Imaging, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Technology Classifications > Research Tools