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Chloroquine-induced Itch is Mediated by Mrgs

C10519: Methods and Compositions for Treating Itch Value Proposition: Inventors have identified a cell receptor family known as Mrgprs that is exclusively expressed in a small subset of neurons. In vitro and animal studies suggest that the Mrg receptor family directly mediates chloroquine (CQ) induced itch. Identification and characterization of Mrgprs...

Published: 7/4/2024 | Inventor(s): David Anderson, Qin Liu, Xinzhong Dong

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Infectious Diseases, Inflammatory Disorders, Itch, Malaria, Mechanism of Action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Neurology > Itch