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A High Throughput Screen Utilizing Newly Discovered Intramolecular Neuronal Calcium Channel interactions to Discover New Analgesics

Unmet NeedChronic pain management continues to be a medical and public health imperative. N-type calcium channel blockers, such as FDA approved Prialt® (ziconotide), have been found to have analgesic effects (blocking pain signals from the nerves to the brain) and to work synergistically with opioids. Unfortunately, drugs like Prialt have serious adverse...

Published: 3/13/2025 | Inventor(s): Heather Agler, David Yue

Keywords(s): Basic Research Biomarker, Cell Model, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain