Search Results - samer+hattar

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A Transgenic Mouse Line for Ablating Cells Positive for Opn4 Expression

TITLE A Transgenic Mouse Line for Ablating Cells Positive for Opn4 Expression CASE NUMBER: C17059 ABSTRACT Rod and cone photoreceptors detect light and relay this information through a multisynaptic pathway to the brain via retinal ganglion cells (RGCs). These retinal outputs support not only...

Published: 4/24/2026 | Inventor(s): Samer Hattar

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Opn4(superscript: tauLacZ/+) Knock-in Mice

TITLE Opn4tauLacZ/+ Knock-in Mice CASE NUMBER: C13016 ABSTRACT The primary circadian pacemaker, in the suprachiasmatic nucleus (SCN) of the mammalian brain, is photoentrained by light signals from the eyes through the retinohypothalamic tract. Retinal rod and cone cells are not required for photoentrainment....

Published: 4/23/2026 | Inventor(s): Samer Hattar, King-Wai Yau

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Opn4(superscript: creERT2/+) Knock-in Mice

TITLE Opn4creERT2/+ Knock-in Mice CASE NUMBER: C13015 ABSTRACT Retinal ganglion cells (RGCs), the output neurons of the retina, have axons that project via the optic nerve to diverse targets in the brain. Typically, RGC axons do not branch before exiting the retina and thus do not provide it...

Published: 4/23/2026 | Inventor(s): Samer Hattar

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology

Opn4(superscript: cre/+) Knock-in Mice

TITLE Opn4cre/+ Knock-in Mice CASE NUMBER: C13014 ABSTRACT Melanopsin is a type of photopigment belonging to a larger family of light-sensitive retinal proteins called opsins and encoded by the gene Opn4. In humans, melanopsin is found in intrinsically photosensitive retinal ganglion cells (ipRGCs)....

Published: 4/23/2026 | Inventor(s): Samer Hattar

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools