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Polymers for Binding-Triggered Antibody Precipitation and Purification

Value PropositionResults in >97% precipitation yield, >88% elution yield of mAbsSimplified molecular design compared to elastin-like polypeptide (ELP)-based materialsDoes not need additional salt to achieve mAb precipitation and recoveryTechnology DescriptionResearchers at Johns Hopkins have developed a peptide-based platform technology using...

Published: 3/14/2025 | Inventor(s): Honggang Cui, Yi Li, David Stern, XuanKuo Xu, Lye Lin Lock, Jason Mills, Sanchayita Ghose, Zheng Jian Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Research Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies

A Novel Supramolecular High Affinity Protein-Binding System for Purification of Biomacromolecules

Market hold: no patent application filed for this invention.Unmet Need· It is estimated that between ~50-80% of costs in antibody production are spent in purification (Mustafaoglu et al. 2016), which is typically performed by affinity chromatography. Although this method has adequate binding affinity and selectivity, the process remains costly...

Published: 3/13/2025 | Inventor(s): Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li

Keywords(s): Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Diagnostics > Biomarkers

Growth and Site-specific Organization of Micro-scale Bimolecular Devices on Living Mammalian Cells

Unmet Need: One aspect of a cell’s function is its ability to form organized structures both within the cell and with its immediate surrounding environment. On cell surfaces, these nanostructures can serve as scaffolds or operate functionally to aid in cellular fate decisions, signal amplification and cellular cross-talk. There is a need to understand...

Published: 3/14/2025 | Inventor(s): Rebecca Schulman, Sisi Jia, Siew Cheng Phua, Yuta Nihongaki, Yizeng Li, Michael Pacella, Yi Li, Abdul Majeed Mohammed, Sean Sun, Takanari Inoue

Keywords(s):

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Determining and Improving Human Egg Quality using microRNAs.

C15916 Marketing SummaryUnmet NeedAccording to the Centers for Disease Control and Prevention, 10% of women (6.1 million) ages 15-44 have difficulty getting pregnant and may turn to assisted reproductive technology (ART), including in vitro fertilization (IVF), for help. Of the 300,000 ART cycles performed in the United States in 2017, only 35% of them...

Published: 3/14/2025 | Inventor(s): Ping Xia, Samarjit Das, Bhuchitra Singh

Keywords(s):

Category(s): Clinical and Disease Specializations > Women's Health > Fertility, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Approaches to Engineering Self-Assembling Peptide Filaments for Protein Binding and Purification

Unmet NeedPeptide amphiphiles (PA) are engineered biomaterials that can self-assemble into nanostructures with specific functions, such as binding to biomarkers for a variety of diseases, binding to specific proteins for purification purposes, or for binding to location specific regions for locally administering drugs. Most PAs currently synthesized...

Published: 3/13/2025 | Inventor(s): Honggang Cui, Yi Li, Lye Lin Lock, XuanKuo Xu, Zhengjian Li

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Reagent

Category(s): Technology Classifications > Research Tools

Method of Fast Imaging of NMR Parameters with Variably-accelerated Sensitivity Encoding (vSENSE)

Unmet Need: Long scan times due to its requirement that multiple saturation-offset image frames be acquired is the underlying reason that widespread clinical use of chemical exchange saturation transfer (CEST) imaging is hampered. Technology Overview: The invention is a novel method that fully samples one CEST saturation frame, then undersamples the...

Published: 3/13/2025 | Inventor(s): Yi Zhang, Jinyuan Zhou, Paul Bottomley

Keywords(s): Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, In Vivo Medical Imaging

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Method of Spatially-encoded NMR Parameters from Arbitrarily-shaped Compartments an Linear Algebraic Modeling

SLAM is a new method to accelerate the acquisition of NMR and MRI measurements that are spatially localized to arbitrarily shaped compartments, many-fold. If compartment-average indices can suffice, SLAM can speed-up clinical or animal studies by up to scores-fold, and generate quantitatively equivalent results to compartment average measures obtain...

Published: 3/13/2025 | Inventor(s): Paul Bottomley, Yi Zhang, Jinyuan Zhou

Keywords(s): Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Recombinant Nanobodies and Derivatives to Study Structure and Function of Wilson Disease Protein (Copper Transporter ATP7B) in vitro and in Cells

UNMET NEEDAn emerging concern in the field of cancer pathology is the reliability and reproducibility of immunohistochemical (IHC), in situ hybridization (ISH), and fluorescence in situ hybridization (FISH) methods to evaluate gene expression and genome alterations in tissues specimens. A tool that could be used to standardize the parameters of IHC...

Published: 3/13/2025 | Inventor(s): Svetlana Lutsenko, Yiping Huang, Serge Muyldermans, Oleg Dmitriev

Keywords(s): Antibodies, Assay, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, Genetic Disorders, In Vitro Diagnostics, Research Reagent, Wilson's Disease

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Wilson's Disease, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

Motion-insensitive, Projection-based MRI Endoscopy Method

C12175: Motion Insensitive MRI EndoscopyNovelty: This technology enables MRI endoscopy to capture clear images despite any patient/endoscope movement.Value Proposition: Patient movement during traditional MRI can dramatically decrease the quality of the resulting images. MRI endoscopy adds yet another moving part. This invention facilitates the use...

Published: 3/13/2025 | Inventor(s): Paul Bottomley, Shashank Sathyanarayana Hegde, Yi Zhang

Keywords(s): Endoscope, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Interventional and Surgical Systems, Magnetic Resonance Imaging (MRI), Surgical Intervention Method

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices > Surgical, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

Method of Spatially-encoded MRS Using Preselected Compartments an Linear Algebraic Modeling

C11462: Novel Method of Performing Localized Magnetic Resonance SpectroscopyNovelty: This is a reduced-to practice method for optimizing both scan time and signal-to-noise (SNR) ratio in Magnetic Resonance Spectroscopy metabolic studies.Value Proposition: Scan time and SNR are major problems for magnetic resonance spectroscopy (MRS) of low-concentration...

Published: 3/13/2025 | Inventor(s): Paul Bottomley, Robert Weiss, Yi Zhang, Refaat Gabr

Keywords(s): Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

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