Search Results - svetlana+lutsenko

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Targeting liver nuclear receptors as a treatment for Wilsons disease

Wilson disease is a hepato-neurologic disorder caused by mutations in the gene ATP7B and accumulation of copper in tissues, predominantly in the liver. The disease is lethal, unless treated. Current life-long treatment involves copper chelation or copper replacement using Zn. Both procedures alleviate major symptoms but side effects are frequent and...

Published: 3/13/2025 | Inventor(s): Svetlana Lutsenko, James Hamilton

Keywords(s): Agonists/Promoters, Biomarker, Disease Indication, Genetic Disorders, Liver, Liver Transplant, Mechanism-of-action Biomarker, Non-novel, Off-the-shelf, Predicted Novelty, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Transplants, Wilson's Disease

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Wilson's Disease, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Transplantation > Liver Transplant, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Transplantation

Recombinant Nanobodies and Derivatives to Study Structure and Function of Wilson Disease Protein (Copper Transporter ATP7B) in vitro and in Cells

UNMET NEEDAn emerging concern in the field of cancer pathology is the reliability and reproducibility of immunohistochemical (IHC), in situ hybridization (ISH), and fluorescence in situ hybridization (FISH) methods to evaluate gene expression and genome alterations in tissues specimens. A tool that could be used to standardize the parameters of IHC...

Published: 3/13/2025 | Inventor(s): Svetlana Lutsenko, Yiping Huang, Serge Muyldermans, Oleg Dmitriev

Keywords(s): Antibodies, Assay, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, Genetic Disorders, In Vitro Diagnostics, Research Reagent, Wilson's Disease

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Genetic Diseases > Wilson's Disease, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Genetic Diseases, Technology Classifications > Research Tools

Polyclonal rabbit antibody against human recombinant Atox1

ABSTRACTAtox1 is a 7.6 kDa cytosolic protein that plays an important role in human copper metabolism. The recombinant intein-fusion of Atox1 was expressed in E.coli, intein tag was cleaved during purification and purified Atox1 was used for immunization of rabbits. Serum containing anti-Atox1 antibodies was tested using mouse liver homogenates and purified...

Published: 3/13/2025 | Inventor(s): Svetlana Lutsenko, Yuta Hatori

Keywords(s): Antibodies, Biologics, Discovery/Research Tools, In Vitro Research Tool, In Vivo Research Tool, Rabbit Model, Research Instrument, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Antibodies