Search Results - know-how

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Efficient, Expansive, User-defined DNA Mutagenesis

C12015: Efficient, Expansive, User-defined DNA MutagenesisNovelty: This invention provides a leap forward in saturation mutagenesis called PFunkel. PFunkel is a next-generation Kunkel mutagenesis strategy that can, for the first time, efficiently and cheaply produce libraries containing user-defined mutations, including sequentially permuted genes....

Published: 3/13/2025 | Inventor(s): Elad Firnberg, Marc Ostermeier

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Know-how

Category(s): Technology Classifications > Research Tools

Deconvolution of polyclonal hepatitis C virus-specific neutralizing antibodies in plasma

Unmet Need: Hepatitis C Virus (HCV) is a leading cause of liver cancer worldwide. Although treatments have been developed, these drugs do not protect against reinfection and are often cost prohibitive to patients. Therefore, there is an urgent need for the development of an effective HCV vaccine. There is currently no efficient method to assess antibody...

Published: 3/14/2025 | Inventor(s): Justin Bailey, Valerie Kinchen, Guido Massaccesi, Stuart Ray, Andrea Lynn Cox

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Know-how

Category(s): Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Infectious Diseases > Hepatitis C Virus (HCV)

Ratiometric Fluorescence Coding Method for Multiplex Nucleic Acid Amplification Assays

Unmet NeedNucleic acid amplification testing (NAAT) is a powerful analytic method that involves the amplification of genetic material, DNA or RNA, for the detection and identification of infectious microbial and viral pathogens like HIV, hepatitis B and C, as well as, oncogene mutations and genetic disorders. One example of its global importance is...

Published: 3/14/2025 | Inventor(s): Tza-Huei Wang, Ye Zhang

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Know-how, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays

Engineered pH-sensitive protein switches

Here we show that a single charge buried in a hydrophobic environment in a protein can stabilize a partially folded protein. This suggests a strategy that will greatly facilitate the study of structural and thermodynamic properties of protein folding intermediates, and also suggests how buried ionizable groups can be used to engineer artificial pH sensing...

Published: 3/13/2025 | Inventor(s): Aaron Robinson, Bertrand Garcia-Moreno

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Know-how, Research Instrument

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors