Search Results - bertrand+garcia-moreno

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Engineered pH-sensitive protein switches

Here we show that a single charge buried in a hydrophobic environment in a protein can stabilize a partially folded protein. This suggests a strategy that will greatly facilitate the study of structural and thermodynamic properties of protein folding intermediates, and also suggests how buried ionizable groups can be used to engineer artificial pH sensing...

Published: 9/26/2024 | Inventor(s): Aaron Robinson, Bertrand Garcia-Moreno

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Know-how, Research Instrument

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Method for Incorporating Internal Polar and Ionizable Groups in Proteins

NOVELTY: This technology comprises a novel method to introduce polar and ionizable groups into the interior of proteins without the loss of protein stability.VALUE PROPOSITION: Currently, the loss of stability related to the introduction of internal ionizable groups has plagued efforts in protein engineering. The disclosed technology overcomes the current...

Published: 9/26/2024 | Inventor(s): Daniel Isom, Bertrand Garcia-Moreno

Keywords(s): Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Molecular Switches/Receptors, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools