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Engineered pH-sensitive protein switches

Here we show that a single charge buried in a hydrophobic environment in a protein can stabilize a partially folded protein. This suggests a strategy that will greatly facilitate the study of structural and thermodynamic properties of protein folding intermediates, and also suggests how buried ionizable groups can be used to engineer artificial pH sensing...

Published: 3/13/2025 | Inventor(s): Aaron Robinson, Bertrand Garcia-Moreno

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Know-how, Research Instrument

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors