Search Results - verena+staedtke

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Neutrophil Suppression as Preconditioning to Increase Efficacies and Safety of Oncolytic Bacterial Therapies

Unmet NeedHypoxia is a prominent feature of solid tumors and can function as fertile environment for oncolytic anaerobic bacteria such as Clostridium novyi-NT (C. novyi-NT) where it can induce tumor destruction in mice and patients. However, two major obstacles have limited its use, namely the host inflammatory response and the incomplete clearance...

Published: 9/27/2024 | Inventor(s): Renyuan Bai, Verena Staedtke

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Oncology > Glioblastoma, Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Therapeutic Modalities > Targets

Preventative Effect of Mebendazole Against Malignancies in Neurofibromatosis 1

Unmet needNeurofibromatosis 1 (NF1) is a common genetic disorder affecting 1 in 3000 individuals worldwide (see CTF). NF1 patients are at a markedly increased risk for the development of benign and malignant tumors that often disfigure the faces of children by the time they are teenagers. Furthermore, when malignant tumors develop they are often resistant...

Published: 9/27/2024 | Inventor(s): Verena Staedtke, Renyuan Bai

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Small Molecules

A Membrane-targeting Construct of NF1 GAP-related Domain (GRD) that Suppresses RAS Activity in NF1-related MPNST, NF1 and other Rasopathies

Unmet NeedNeurofibromatosis type 1 (NF1) is a common genetic disorder that affects approximately 1 in 3,000 individuals worldwide. Patients with NF1 have DNA alterations to the neurofibromin 1 gene which cause RASopathies, a family of diseases caused by altered Ras signaling. RASopathies can include both benign and malignant tumors, including malignant...

Published: 9/26/2024 | Inventor(s): Verena Staedtke, Renyuan Bai

Keywords(s): Adeno-Associated Virus, Biologics, Cancers, Discovery/Research Tools, Disease Indication, Nucleic Acid, Research Reagent, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Viruses

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Research Tools > Vectors & Plasmids