Search Results - sandra+gabelli

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High Affinity Nanobodies Specific for Voltage Gated Sodium Channels

Unmet Need Globally, millions of patients are affected by diseases caused when mutations affect the normal function of voltage gated sodium channels (Nav). These mutations have been implicated in several human genetic diseases such as hypokalemic periodic paralysis, myotonia and Brugada syndrome. Myotopic Dystrophy alone affects at least 1 in 8,000...

Published: 9/27/2024 | Inventor(s): Sandra Gabelli, L. Mario Amzel, Lakshmi Srinivasan, Vanina Alzogaray, Manu Ben-Johny

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Phosphatidylinositol 3-kinase (alpha) Expression Vectors

ABSTRACTResearchers at Johns Hopkins University have developed a set of plasmids that express recombinant P110a/niP85a heterodimer providing the means to purify large quantities of a fusion protein containing the full length phosphatidylinositol 3 kinase alpha (P110α) in complex with residues 322-600 of the regulatory subunit p85. The fusion protein...

Published: 9/26/2024 | Inventor(s): Bert Vogelstein, Sandra Gabelli

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools