Detection of circulating methylated DNA for high-sensitivity cancer diagnostic and treatment planning
Report of Invention:
5/3/2012
Web Published:
12/13/2021
Unmet Need / Invention Novelty: Circulating tumor-associated methylated DNA is an important biomarker for early detection of cancer, risk assessment, predicting and monitoring response to therapy and early detection of relapse. Current tests designed to detect methylated tumor DNA in patient fluids such as the serum and plasma are challenged by low and fluctuating amounts of methylated tumor DNA, lack of sensitivity, and unreliable detection of target DNA quantities. There is an unmet need to develop a sensitive, reliable and quantitative method for detecting circulating methylated tumor DNA.
Technical Details: Researchers at Johns Hopkins have developed a novel method for the detection of circulating methylated tumor DNA. The method, termed cMethDNA, is a derivative of their previously disclosed tissue-based quantitative multiplex methylation specific PCR (QM-MSP). cMethDNA can quantitatively detect low copy number tumor DNA methylation patterns in serum and plasma with high sensitivity and specificity. Proof of concepts studies demonstrated highly specific and sensitive detection of circulating methylated tumor DNA from the sera of breast cancer patients. A small prospective clinical validation study also demonstrated the capability of cMethDNA to monitor response post treatment and prognosticate outcome.
Value Proposition: - Diagnostic and prognostic epigenetic biomarker detection method
- Enables detection at low copy number
- Highly sensitive (>90%) and specific (>96%)
- Applicable to circulating tumor DNA or other diseases with aberrant methylation
Looking for Partners to: Develop & commercialize as a novel method for cancer diagnosis and optimized treatment planning. Stage of Development: Pre-Clinical Data Availability: in vitro validation with patient sera Inventors: Saraswati Sukumar, Mary Jo Fackler, Antonio Wolff, Zoila Lopez Bujanda, Wei Wen Teo
Publication(s)/Related Technology:
Patent Information:
Title |
App Type |
Country |
Serial No. |
Patent No. |
File Date |
Issued Date |
Expire Date |
Patent Status |
A QUANTITATIVE MULTIPLEX METHYLATION SPECIFIC PCR METHOD- cMethDNA, REAGENTS, AND ITS USE |
PCT: Patent Cooperation Treaty |
Japan |
2015-514150 |
|
5/22/2013 |
|
|
Pending |
A Quantitative Multiplex Methylation Specific for PCR method - cMethDNA, Reagents, and Its Use |
PCT: Patent Cooperation Treaty |
Australia |
2013266341 |
2013266341 |
5/22/2013 |
4/18/2019 |
5/22/2033 |
Granted |
QUANTITATIVE MULTIPLEX METHYLATION SPECIFIC PCR METHOD- cMethDNA, REAGENTS, AND ITS USE |
PCT: Patent Cooperation Treaty |
China |
201380039009.7 |
ZL201380039009.7 |
5/22/2013 |
5/1/2018 |
5/22/2033 |
Granted |
A Quantitative Multiplex Methylation Specific for PCR method - cMethDNA, Reagents, and Its Use |
PCT: Patent Cooperation Treaty |
Canada |
2,874,035 |
|
5/22/2013 |
|
|
Pending |
A Quantitative Multiplex Methylation Specific for PCR method - cMethDNA, Reagents, and Its Use |
PCT: Patent Cooperation Treaty |
European Patent Office |
13794493.0 |
2852690 |
5/22/2013 |
8/26/2020 |
5/22/2033 |
Granted |
A Quantitative Multiplex Methylation Specific for PCR method - cMethDNA, Reagents, and Its Use |
PCT: Patent Cooperation Treaty |
France |
13794493.0 |
2852690 |
5/22/2013 |
8/26/2020 |
5/22/2033 |
Granted |
A Quantitative Multiplex Methylation Specific for PCR method - cMethDNA, Reagents, and Its Use |
PCT: Patent Cooperation Treaty |
Germany |
13794493.0 |
2852690 |
5/22/2013 |
8/26/2020 |
5/22/2033 |
Granted |
A Quantitative Multiplex Methylation Specific for PCR method - cMethDNA, Reagents, and Its Use |
PCT: Patent Cooperation Treaty |
United Kingdom |
13794493.0 |
2852690 |
5/22/2013 |
8/26/2020 |
5/22/2033 |
Granted |
QUANTITATIVE MULTIPLEX METHYLATION SPECIFIC PCR METHOD- cMethDNA, REAGENTS, AND ITS USE |
PCT: Patent Cooperation Treaty |
United States |
14/402,434 |
10,450,609 |
11/20/2014 |
10/22/2019 |
5/1/2035 |
Granted |
QUANTITATIVE MULTIPLEX METHYLATION SPECIFIC PCR METHOD- cMethDNA, REAGENTS, AND ITS USE |
DIV: Divisional |
United States |
16/601,269 |
|
10/14/2019 |
|
|
Pending |
|
|
Inventors:
Category(s):
Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools,
Get custom alerts for techs in these categories/from these inventors:
|