Search Results - david+huso

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Gene silencing technology for the treatment of triple negative breast cancer

Invention Novelty: The given invention proposes an efficient technology for the treatment of triple negative breast cancer Value Proposition: Often associated with rapid progression and poor outcomes, Triple Negative Breast Cancer (TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR)...

Published: 10/3/2024 | Inventor(s): Leslie Cope, David Huso, Linda Smith Resar

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Development of Mice with Targeted Deletions of the TEM-1 Gene

C10782: TEM1 (CD164L1/ endosialin) Knockout MiceValue Proposition: JHU scientists have generated a mouse model with a targeted null mutation in the Tem1 gene. They demonstrate that Tem1 is not required for angiogenesis during fetal development, postnatal growth, or wound healing; however, Tem1 plays a critical role in determining tumor behavior in clinically...

Published: 10/3/2024 | Inventor(s): Kenneth Kinzler, David Huso, Akash Nanda, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancers, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology