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Development of Mice with Targeted Deletions of the TEM-1 Gene

C10782: TEM1 (CD164L1/ endosialin) Knockout MiceValue Proposition: JHU scientists have generated a mouse model with a targeted null mutation in the Tem1 gene. They demonstrate that Tem1 is not required for angiogenesis during fetal development, postnatal growth, or wound healing; however, Tem1 plays a critical role in determining tumor behavior in clinically...

Published: 3/13/2025 | Inventor(s): Kenneth Kinzler, David Huso, Akash Nanda, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cancers, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology