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Novel Proteins for Diagnosis and Treatment of Acute Kidney Injury

Novel Proteins for Diagnosis and Treatment of Acute Kidney Injury (AKI)JHU Ref #: C17069 Value PropositionInvention provides compositions and methods useful for the diagnosis and treatment of acute kidney injury (AKI)Demonstrates the feasibility of using a multiomics approach to discover novel, noninvasive markers of AKI that are associated with adverse...

Published: 3/14/2025 | Inventor(s): Chirag Parikh, Yumeng Wen

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Device and Method to produce Dialysate

Unmet NeedAcute kidney injury is common among critically ill patients, and has an associated mortality rate of 30% to 70% [1]. Continuous veno-venous hemodialysis (CVVHD) is a treatment for acute kidney injury that uses diffusive clearance to remove toxins and solutes from the patient’s circulation. In CVVHD, dialysate, which is a nonsterile aqueous...

Published: 3/14/2025 | Inventor(s): Chirag Parikh, Derek Fine, Mohit Singhala, Ryan Bell, Brielle Cenci

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Category(s): Clinical and Disease Specializations > Nephrology, Technology Classifications > Therapeutic Modalities

Reduce Discard of Kidneys for Transplantation after Brain Death using Repair Biomarkers

Unmet Need:The prevalence of end-stage renal disease (ESRD) is predicted to rise sharply over the next few decades due to an aging population and an increased incidence of diabetes and hypertension. ESRD patients that receive a kidney transplant have improved outcomes compared to patients that remain on dialysis; however, of the 100,000 dialysis patients...

Published: 3/14/2025 | Inventor(s): Chirag Parikh

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Category(s): Technology Classifications > Therapeutic Modalities