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Combination therapy targets intrinsic cancer resistance to nucleoside DNA methyltransferase inhibitors.

Unmet NeedGenome stability is regulated by a variety of mechanisms. One such mechanism is DNA methylation. DNA methylation can alter the manner in which genes are expressed, and aberrations in methylation management are well documented as features of cancer cells. DNA methylation is regulated in part by enzymes known as DNA methyltransferases (DNMTs)....

Published: 3/14/2025 | Inventor(s): Srinivasan Yegnasubramanian, Jianyong Liu, William Nelson, Jun Liu

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Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications, Technology Classifications > Therapeutic Modalities > Small Molecules