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Spatial Analysis of RNA Using Probe Ligation and Amplification in situ

Unmet Need Traditional gene expression methods that use bulk RNA analysis lack the ability to resolve transcript location, and thus fail to capture the inherent cellular heterogeneity present in virtually every tissue. Abundance and localization of RNA transcripts mapped to specific regions of tissue can complement histological analysis, providing an...

Published: 1/28/2026 | Inventor(s): Harry Larman, Joel Credle

Keywords(s):

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Improved Integrated Robotic Intraocular Snake

Value Proposition· Dexterous distal unit minimizes contact stress on delicate eye tissues· Enables precise manipulation· Innovative wire drive mechanism enhances accuracy· Instrument can be detached from the motor unit, facilitating cleaning, sterilization, and the attachment of various surgical tools· Extremely lightweight,...

Published: 1/28/2026 | Inventor(s): Iulian Iordachita, Makoto Jinno

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Surgery, Technology Classifications > Medical Devices > Surgical, Clinical and Disease Specializations > Ophthalmology > Retinal Detachment, Clinical and Disease Specializations > Ophthalmology > Retinal Degeneration, Clinical and Disease Specializations > Ophthalmology > Diabetic Retinopathy, Clinical and Disease Specializations > Ophthalmology > Retinopathy, Clinical and Disease Specializations > Ophthalmology > Retinal Vein Occlusion

Long Term Storage and Improved Mechanical Properties of Implantable Vascular Grafts

Technical Problem Current synthetic small-diameter tissue engineered vascular grafts face challenges such as thrombogenicity, decreased elasticity, aneurysmal failure, calcification, and intimal hyperplasia, limiting their clinical effectiveness for pediatric congenital cardiovascular defects, coronary artery disease, and peripheral artery disease,...

Published: 1/27/2026 | Inventor(s): Sharon Gerecht, Morgan Elliott, Hai-Quan Mao, Jessica Shen

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities > Tissue Substrates, Technology Classifications > Medical Devices > Cardiology

Methods and Systems for Insertion of a Medical Device during a Medical Imaging Process

Technical Problem Current medical procedures for prostate biopsy and therapy face challenges with inaccurate needle placement due to dynamic tissue deformation and limited access within closed MRI scanners, where traditional robots and mechanical linkages are not compatible and suffer from low signal-to-noise ratio and invasive methods. How it...

Published: 1/27/2026 | Inventor(s): Gabor Fichtinger, Iulian Iordachita, Louis Whitcomb, Robert Susil, Ergin Atalar, Axel Krieger

Keywords(s): Interventional and Surgical Systems, Surgical Navigation

Category(s): Technology Classifications > Medical Devices > Surgical, Technology Classifications > Medical Devices

Abdominal Multi-Organ Segmentation with Organ-Attention Networks

Value Proposition· Higher accuracy: Uses a novel organ-attention mechanism to reduce false positives and improve organ boundaries· Integrated view predictions: Utilizes axial, sagittal, and coronal images to produce robust and consistent organ labels· Rapid approach: Utilizes accessible GPU hardware over stronger, but slower, alternatives· Highly...

Published: 1/22/2026 | Inventor(s): Alan Yuille, Elliot Fishman, Seyoun Park, Yan Wang, Yuyin Zhou, Wei Shen

Keywords(s): Computer and Network Systems, Computer Software, Image Analysis Software

Category(s): Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis

PSMA-targeted Nanoparticles for Therapy of Prostate Cancer

PSMA-targeting nanoparticle for prostate cancer therapyJHU Ref #: C10180Value Proposition:· Engineered nanoparticle system with potent urea-based PSMA inhibitor· Drug loaded nanoparticle· Specific and selective tumor cytotoxicity Unmet NeedProstate cancer affects millions of men globally and is a leading cause of cancer death in...

Published: 1/22/2026 | Inventor(s): Martin Pomper, Ronnie Mease, Sachin Chandran, Sangeeta Ray, Samuel Denmeade

Keywords(s): Cancers, Disease Indication, Drug Delivery Vehicle, Nanoparticles, Prostate Cancer, Single, Targeted Therapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Prostate Cancer

A CRISPR-based technology to treat cytomegalovirus (CMV) and other Viral Infections.

Value Proposition Novel Mechanism: Utilizes a Crispr/Cas9 system to target the viral genome to prevent production of the disease-causing protein 1E1 in CMV. Widely Adaptable: Design allows modulation to fit a wide variety of other viral genomes to combat other infectious diseases. Therapeutic Potential: Administration of proposed technology to...

Published: 1/28/2026 | Inventor(s): Akira Sawa, Koko Ishizuka, Kazuhiro Ishii, Stephanie Tankou

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Cytomegalovirus, Technology Classifications > Therapeutic Modalities > Gene Therapies

MS-cleavable Photo-crosslinkers for Proteome-wide Photo-crosslinking Mass Spectrometry

Reagents for Crosslinking Mass SpectrometryJHU Ref #: C17605 Value Proposition:• MS-cleavable crosslinkers for capturing protein-protein interactions. • Compounds feature an NHS group and diazirine for covalent non-specific residue linkages.• Avoid the N2 problem. • Compounds are water-soluble and cell-permeable. Technology DescriptionResearchers at...

Published: 1/22/2026 | Inventor(s): Piyoosh Sharma, Stephen Fried, Anneliese Faustino

Keywords(s):

Category(s): Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Peptides

The Role of IL17 in Age-related Immune-stromal Network Inhibiting Response to Regenerative Immunotherapy

Combination immunotherapy to enhance tissue regeneration in the elderly JHU Ref #: [C17006] Value Proposition· Regenerative medicine strategies aim to restore or replace damaged tissues and organs, with patients suffering from chronic diseases, injuries, and degenerative conditions as the end-users of regenerative medicine therapies.· Current...

Published: 1/22/2026 | Inventor(s): Jennifer Elisseeff, Jin Han, Christopher Cherry, Drew Pardoll

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Fibrosis, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Traumatic Injury, Clinical and Disease Specializations > Wound Healing

INCERTS Methodology for Multiplexing Single Cell Analyses via cDNA Barcoding

A method for integrating cellular phenotype with T cell receptor analysisJHU Ref #: C17820 Value Proposition:· Paired TCR sequencing and phenotypic analysis· High throughput and resolution· Enables pooling of samples Unmet NeedCharacterization of the adaptive immune response has been advanced by single cell RNA-sequencing (scRNA-seq)...

Published: 1/22/2026 | Inventor(s): Harry Larman, Janelle Montagne, Sahana Jayaraman

Keywords(s):

Category(s): Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

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