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Generative Language Model for Antibody Sequence Design (IgLM)

Unmet NeedMonoclonal antibody therapies have become an extremely popular and effective treatment route for cancer, rheumatoid arthritis, and infectious diseases. At present, there are over 100 FDA approved monoclonal antibody therapies with many more in late stage clinical trials (see Nature). One approach that is commonly used to generate monoclonal...

Published: 4/24/2026 | Inventor(s): Jeffrey Gray, Jeffrey Ruffolo, Richard Shuai

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Algorithms, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence, Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Therapeutic Modalities > Antibodies, Copyright

A chemical agent for the selective production of DNA-protein crosslinks

Value Proposition· Demonstrated selectivity (40x) for production of DNA-protein cross link (DPC) formation as compared to DNA-DNA interstrand cross-link (ICL) formation.· Robust DPC formation shown in both nucleosome core particles and live human cell lines. · High yield of DNA-protein cross links with similar cellular toxicity as traditional...

Published: 4/24/2026 | Inventor(s): Marc Greenberg

Keywords(s):

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

Dual-Target Vascular Endothelial Growth Factor (VEGF) Therapy for Treating Ocular Neovascularization

Value Proposition· Comprehensive Targeting: Engineered antagonist proteins combine elements of both VEGF receptor (VEGFR)-1 and VEGFR-2 to target all human VEGF ligands and sequester 2 ligand homodimers simultaneously.· Superior Inhibition: Comprehensive ligand blockade inhibits neovascularization more effectively than existing VEGF-A only...

Published: 4/24/2026 | Inventor(s): Jamie Spangler, Raquel Formica, Peter Campochiaro, Paul Sargunas

Keywords(s):

Sutureless Adhesive Connectors for Tissue Repair

Value Proposition· Eliminates the need for time-consuming microsurgical sutures for tubular organ repair, reducing operative time and anesthesia exposure.· Minimizes additional tissue trauma caused by suturing, improving functional recovery and reducing complications.· Uses biodegradable materials and engineered adhesives/nanostructures...

Published: 4/23/2026 | Inventor(s): Hai-Quan Mao, Ahmet Hoke

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

A microRNA for treatment of childhood medulloblastoma

Value PropositionTargets specifically to medulloblastomaReduces tumorigenicity in vitro and in vivoNanoparticle encapsulation is capable of enhanced miRNA deliveryUnmet Need:Medulloblastoma is a malignant embryonal tumor of the cerebellum and brainstem that accounts for roughly 15–20% of pediatric brain tumors and is the most common solid tumor in children...

Published: 4/24/2026 | Inventor(s): Ranjan Perera, Sudipta Seal, Justin Hanes, Kannan Rangaramanujam

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Medulloblastoma, Technology Classifications > Therapeutic Modalities > Gene Therapies

Inner Ear-Specific Cre Mouse Model for Targeted Gene Deletion and Hearing Loss Research

JHU Ref #: C15757Value Proposition· Inner ear specificity: When bred with a mouse with a floxed gene of interest (GOI), the offspring will not express the GOI in the inner ear. · Applicable in multiple hearing models: Researchers can study effects of a GOI in the inner ear in both deaf and hearing mice.· Improved mouse line stability:...

Published: 4/24/2026 | Inventor(s): Dwight Bergles, Travis Babola

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Ear, Nose & Throat > Hearing Disorders, Technology Classifications > Research Tools

A Transgenic Mouse Line for Ablating Cells Positive for Opn4 Expression

TITLE A Transgenic Mouse Line for Ablating Cells Positive for Opn4 Expression CASE NUMBER: C17059 ABSTRACT Rod and cone photoreceptors detect light and relay this information through a multisynaptic pathway to the brain via retinal ganglion cells (RGCs). These retinal outputs support not only...

Published: 4/24/2026 | Inventor(s): Samer Hattar

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

Multi Region Brain Organoid (MRBO)

Multi-Region Brain Organoids (MRBOs)A TechBio platform that pairs the most physiologically faithful human brain tissue with AI-driven computational genomics to generate proprietary CNS drug discovery insights no other system can produce.The ProblemCNS drug development has the highest failure rate of any therapeutic area, and the root cause is computational,...

Published: 4/24/2026 | Inventor(s): Annie Kathuria

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Research Tools

Cell-type specific technique for neuron projection mapping

Value Proposition• Able to target specific populations of neurons in connectome profiling • High-throughput projection mapping at the single-neuron level• Can discriminate molecular or connectomic cell types among targeted neurons• Sequencing-based approach enables fast and accurate results Unmet NeedUnderstanding the mechanisms by which neurons establish...

Published: 4/24/2026 | Inventor(s): Justus Kebschull, Hyopil Kim, Huihui Qi

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Bioinformatics

Treatment of mucus-related diseases via modulation of mechanosignaling pathways activated by high mucus viscosity

Value Proposition· Restoration of pro-repair cell dynamics: targets the high mucus viscosity that drives exacerbation of muco-obstructive lung diseases (COPD, CF, IPF)· Addresses biophysical mechanism of disease development: disrupts the counter-reparative mechanosignaling pathway activated by elevated mucus viscosity· Cell type-specific...

Published: 4/28/2026 | Inventor(s): Yun Chen, Matthew Pittman, Sergey Plotnikov, Daniel Yan

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities

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