Search Results - other

2021 Results

Sort By:

Intra/Inter-Molecular Hydrogen Bonding Stabilized, Amino Acid/peptide Modified Redox-active Sorbents for Electrochemical Carbon Dioxide Separation

High Affinity, Redox-Active Sorbents for Electrochemical Carbon Capture JHU Ref #: C17628 Unmet Need In recent years, global carbon emissions have increased dramatically. Even with renewable energy sources, carbon capture is seen as the only practical method to reduce industrial emissions to meet short term criteria for preventing global warming....

Published: 6/28/2024 | Inventor(s): Yayuan Liu, Xing Li

Keywords(s):

Category(s): Technology Classifications > Industrial Tech, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Engineering Tech > Energy, Infrastructure & Environment, Technology Classifications > Engineering Tech > Industrial Manufacturing, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Industrial Tech > Materials, Technology Classifications > Engineering Tech

Uses of PSMA- and TSPO-targeting Compounds for Evaluation of Injuries in the Peripheral Nervous System

Value Proposition:· Technology combines positron emission tomography (PET) with targeted imaging compounds for a first-in-class approach to peripheral nerve injury (PNI) evaluation and monitoring.· Provides a method for non-invasive evaluation of PNI status immediately post-injury and over the recovery timeline. · Implementation...

Published: 6/28/2024 | Inventor(s): Martin Pomper, Catherine Foss, Sami Tuffaha, William Padovano

Keywords(s):

Category(s):

Combination therapy targets intrinsic cancer resistance to nucleoside DNA methyltransferase inhibitors.

Unmet NeedGenome stability is regulated by a variety of mechanisms. One such mechanism is DNA methylation. DNA methylation can alter the manner in which genes are expressed, and aberrations in methylation management are well documented as features of cancer cells. DNA methylation is regulated in part by enzymes known as DNA methyltransferases (DNMTs)....

Published: 6/28/2024 | Inventor(s): Srinivasan Yegnasubramanian, Jianyong Liu, William Nelson, Jun Liu

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications, Technology Classifications > Therapeutic Modalities > Small Molecules

18F-Labeled PET Radiotracers for Imaging Neuroinflammation in the Brain

Value Proposition:· Quantification and PET imaging of microglial cells in the brain· Diagnostic for neuroinflammatory disorders – Alzheimer’s and MS· Favorable compound half-life enables shipping· Potential for non-CNS applications Technology DescriptionResearchers at Johns Hopkins have developed a series of Positron Emission Tomography...

Published: 6/28/2024 | Inventor(s): Martin Pomper, Deepankar Das, Andrew Horti, Wojciech Lesniak

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

Novel Oxazolidinone Antibacterials and the Synthetic Routes to Them

Marketing Summary Draft Novel Oxazolidinone Antibacterials and the Synthetic Routes to ThemJHU Ref #: C18144Value Proposition· Higher efficacy and lower toxicity oxazolidinone compounds· Positive activity demonstrated against M. abscessus· MIC values are the same or better than the current antibiotics in the market Unmet Need The...

Published: 6/28/2024 | Inventor(s): Gyanu Lamichhane, J. Ippoliti, Cole Friederichs, Connor Winkelhake, Ben Thompson, Kelsey Latterell

Keywords(s):

Category(s):

Chemically Inducible Hetero-trimerization Tool

Marketing Summary DraftChemically Inducible Hetero-trimerization ToolJHU Ref #: C16287Value Proposition· Chemically Inducible Trimerization (CIT) for introducing a third recruitable component· Addition of rapamycin through rational splitting of FKBP and FRB leads to efficient trimerization· Has robust cellular applications e.g.,...

Published: 6/28/2024 | Inventor(s): Takanari Inoue, Di Wu, Masaki Kikuchi, Onur Dagliyan, Hideki Nakamura, Nikolay Dokholyan, Takashi Umehara

Keywords(s):

Category(s):

Intracellular actuator that generates and manipulates physical force in living cells

Marketing Summary DraftIntracellular actuator that generates and manipulates physical force in living cellsJHU Ref #: C14896Value PropositionPhysical force generation inside living cells via light irradiation and chemical treatmentThis research tool can be applied to arbitrary intracellular targets in a specific and spatiotemporal mannerSystem is built...

Published: 6/27/2024 | Inventor(s): Takanari Inoue, Hideki Nakamura, Elmer Rho

Keywords(s): Discovery/Research Tools, Peptides, Recombinant Proteins, Research Reagent, Translational Research Biomarker

Category(s):

Novel Oxazolidinones for Treatment of Bacterial Infections

Marketing Summary DraftNovel Oxazolidinones for Treatment of Bacterial InfectionsJHU Ref #: C14633Value Proposition· Belong to the same chemical family as Zyvox, marketed by Pfizer, but shows better efficacy· Positive activity demonstrated against M. tuberculosis· MIC values the same or better than the current antibiotics in the...

Published: 6/27/2024 | Inventor(s): Gyanu Lamichhane, J. Ippoliti

Keywords(s): Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Selective and Specific Cell Killing Tool

Unmet NeedPancreatic cancer is a highly lethal malignancy and it is the fourth leading cause of cancer-related death in the United States (see Uptodate). Surgical resection is currently the only potential treatment to cure pancreatic cancer that could result in significant improvement in survival, but over 80% of patients with pancreatic cancer are...

Published: 6/28/2024 | Inventor(s): James Eshleman, Selina Shiqing Teh, Kirsten Cunningham-Bowland, Nicholas Roberts

Keywords(s):

Category(s):

Small Molecule Neutral Sphingomyelinase 2 (nSMase2) Inhibitors

Unmet NeedNeutral sphingomyelinase 2 (nSMase2) is expressed in neurons and hydrolyzes sphingomyelin, producing the lipid ceramide, which functions in stress responses leading to apoptosis, cell growth arrest, and differentiation. Increased levels of ceramides have been associated with many neurological disorders, including Alzheimer’s disease, multiple...

Published: 6/27/2024 | Inventor(s): Takashi Tsukamoto, Niyada Hin, Ondrej Stepanek, Barbara Slusher, Camilo Rojas, Ajit Thomas

Keywords(s): Antagonists/Inhibitors, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules

1 2 3 4 5 6 7 8 9 10 ...