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Polymeric particles for sustained delivery of multimodal peptide therapeutics

Polymeric particles for sustained delivery of multimodal peptide therapeutics JHU Ref #: C11250 Value Proposition · Stability: polymeric nanoparticle encapsulation increases and sustains peptide residence time, for increased accumulation in tissue vasculature and maximize treatment effects · Safety: use of nanoparticles...

Published: 10/27/2025 | Inventor(s): Jordan Green, Aleksander Popel, Joel Sunshine, Ron Shmueli, Stephany Tzeng, Kristen Kozielski

Keywords(s): Biologics, Drug Delivery Vehicle, Nucleic Acid, Peptide, Polymers, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities

TH-2A-CreER Mice

Value Proposition· Enhanced labeling efficiency: The TH-2A-CreER mouse line achieves higher labeling efficiency compared to existing mouse lines through the 2A peptide system that ensures elevated CreER expression levels· Multi-population targeting: Enables labeling and functional manipulation of TH-expressing neuronal populations including...

Published: 10/23/2025 | Inventor(s): David Ginty

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Cationic Polymers with Biphasic Biodegradation

Value Proposition· Delivery Efficacy: Demonstrates more effective gene delivery to cancer associated fibroblasts (CAFs) or human primary fibroblasts than industry gold-standards such as Lipofectamine 2000 and polyethylenimine (PEI).· Cargo Compatibility: Enables encapsulation and delivery of a wide range of cargos including, DNA, RNA,...

Published: 10/23/2025 | Inventor(s): Stephany Tzeng, Ron Shmueli, Nupura Bhise, Joel Sunshine, Jordan Green

Keywords(s): Drug Delivery Vehicle, Polymers, Therapeutic Matter, Therapeutics

3D Lattice Weaves with Tailored Damping Properties

3D woven NiCr metallic lattice materials deliver tunable, structural damping in environments where conventional polymer-based solutions fail, enabling more reliable, longer‑life high‑temperature machinery and structures with a scalable, architected-metal manufacturing route. Problem addressed Rotating machinery and high‑speed systems (e.g., turbines)...

Published: 10/23/2025 | Inventor(s): James Guest, Kevin Hemker, Timothy Weihs, Stephen Ryan, Stefan Szyniszewski

Keywords(s): Alloyed Materials (Alloys), Industrial Manufacturing, Novel Materials

Category(s): Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech > Materials, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Industrial Manufacturing, Technology Classifications > Engineering Tech > Materials

Proinflammatory Immature Myeloid Cells and Their Use in Treatment of Cancer

Value Proposition:· Gene-editing approach creates myeloid cells polarized into a pro-inflammatory phenotype.· Engineered cells persist even in an immune-suppressive environment. · High potential as anti-cancer therapy, as cells are present in all tissues and can easily infiltrate tumors. · Cells demonstrate robust expression of pre-inflammatory...

Published: 10/24/2025 | Inventor(s): Alan Friedman

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Gene Therapies, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Immuno-Oncology

Scalable Distributed Tactile Sensors without Integrated Circuits using Resonance Multiplexed Piezoelectric Sensors

Value Proposition· Scalable sensor array capable of functioning in extreme environments, including in high radiation and underwater· Resolves dynamic forces over a wide range · Only requires a few interfacing wires regardless of the number of sensing units· Provides simultaneous proprioceptive insights and force recordings with...

Published: 10/24/2025 | Inventor(s): Ariel Slepyan

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Sensors

Electrochemical Hydrometallurgy for Sustainable Ironmaking

Value Proposition· Achieves a tenfold improvement in cost-to-value efficiency per ton of feedstock compared to conventional ironmaking· Reduces carbon emissions, minimizes reagent consumption and waste, enables carbon sequestration, and incorporates a circular reagent economy· Eliminates the need for dual-cell electrowinning configurations,...

Published: 10/24/2025 | Inventor(s): Chao Wang, Chengao Zhou, Yulin Liu, Hao Shen

Keywords(s):

Category(s): Technology Classifications > Engineering Tech > Energy, Infrastructure & Environment, Technology Classifications > Engineering Tech > Industrial Manufacturing, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech > Materials

A method for inhibiting UHRF1 in colorectal cancer

Value PropositionReversal of colorectal cancer-specific DNA hypermethylationmRNA-based strategy for UHRF1 inhibitionA lipid nanoparticle-based delivery platformUnmet Need1 out of 24 people will develop colorectal cancer. Current technologies do not maximize the bodies’ native ability to suppress tumors. Existing therapies lack specificity and cause...

Published: 10/24/2025 | Inventor(s): Stephen Baylin, Srinivasan Yegnasubramanian, Ying Cui, Xiangqian Kong

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Method for Making Ultrasonic Transducer Device

JHU Ref #: [C17108, C17833, and C17521]Value Proposition· Wearable, Patch-Based Technology: Designed to autonomously monitor and/or treat biological features, enabling rapid, non-invasive triage and care in emergency settings.· Three Sensing Modalities: A handheld device collects and displays the real-time physiological data of multiple...

Published: 10/24/2025 | Inventor(s): Amir Manbachi, Haley Abramson, Joshua Punnoose, Aliaksei Pustavoitau, Kelley Leadingham, Nicholas Nowicki, David Gerke, Jeff Corgan, George Coles

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Systems and Methods for Monitoring and Treatment of an Injury (HEPIUS)

JHU Ref #: [C15551, C17109, C17520, C17716]Value Proposition· Real-Time Physiological Monitoring: Provides continuous, high-resolution images of the spinal cord and microvasculature, enabling real-time assessment of spinal cord blood flow (SCBF) to determine points of intervention and mitigate secondary phase injury following spinal cord injury...

Published: 10/24/2025 | Inventor(s): Amir Manbachi, Nicholas Theodore

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