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Targeted Nano-Delivery of Aurora Kinase Inhibitors for Cancer Therapy

Value Proposition· Kinase inhibition is a highly effective, targeted therapy that is standard of care for many cancers.· Aurora kinase inhibition is a promising class of these therapeutics demonstrated to successfully inhibit tumor growth and promote patient survival in various cancer indications. However, current oral administration requires...

Published: 7/24/2026 | Inventor(s): Sudath Hapuarachchige

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications, Technology Classifications > Therapeutic Modalities > Repurposed Drugs

Biodegradable Nanofiber Conical Conduits for Targeted Muscle Reinnervation

Unmet NeedThere are 2 million amputees in the United States, with limb loss attributed to diabetes mellitus, vascular disease, trauma, and malignancy of bone and joints (Amputee Coalition, 2021 and Ziegler-Graham, et al., 2008). Living with an amputation and the adoption of assistive devices like prosthetics can be challenging, with chronic pain especially...

Published: 7/24/2026 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Ahmet Hoke, Michael Lan, Bruce Enzmann, Anson Zhou, Alison Wong, Erica Lee, Sai Pinni

Keywords(s):

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Orthopedic Devices

Particulate Drug Delivery System to Enable Targeted Ultrasound-gated Release of Neuromodulatory Agents

Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Towards this goal, the JHU scientists have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug upon the application of focused ultrasound. These nanoparticles are composed of biodegradable...

Published: 7/24/2026 | Inventor(s): Jordan Green, Raag Airan, Randall Meyer

Keywords(s): CNS and Neurological Disorders, Disease Indication, Drug Delivery Mechanism, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Nerve Disorders and Injury, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices > Neurostimulation

A Blood Test for Postpartum Depression

Value Proposition:High sensitivity and specificity: multiplex biomarker assay to diagnose and detect risk of postpartum depression (PPD).Minimally invasive assay: PPD biomarker panel easily detected in blood plasma or serum samples.Rapid and accurate: Assay can quickly and accurately detect low level extracellular vesicle-associated nucleic acid biomarkers...

Published: 7/24/2026 | Inventor(s): Sarven Sabunciyan, Jennifer Payne, Lauren Osborne

Keywords(s):

Category(s): Clinical and Disease Specializations > Psychiatry > Postpartum Depression, Technology Classifications > Diagnostics

Quantitative HIV diagnostic that detects mutational burden

Value PropositionStraightforward and scalable: Researchers at Johns Hopkins have created a diagnostic assay that can quantify viral HIV particles in plasma and, at the same time, predict whether they are replication competent.Sensitive and low cost: This diagnostic tool can detect low levels of viremia and distinguish single mutations without the need...

Published: 7/24/2026 | Inventor(s): Francesco Simonetti

Keywords(s):

Category(s): Clinical and Disease Specializations > Research Tools > Assays, Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS

A novel software package for detection and analysis of rare genomic variants

Value Proposition· Clinical Genomics Gap Addressed: This technology directly targets the systematic underdetection of rare pathogenic germline variants by current industry-standard pipelines, a gap with direct consequences for hereditary cancer diagnosis, trial enrollment, and treatment eligibility.· Novel Ensemble Approach: Rather than...

Published: 7/24/2026 | Inventor(s): Jun Luo, Daniel Rabizadeh

Keywords(s):

Category(s): Technology Classifications > Research Tools, Technology Classifications > Computers, Electronics & Software

Urine Based Test for Prostate Cancer

Value Proposition· Non-invasive prostate cancer detection: A urine-based biomarker panel may enable identification of prostate cancer without the discomfort, risk, or logistical burden of an invasive biopsy.· Improved diagnostic accuracy: Early data show strong sensitivity and specificity for detecting prostate cancer, supporting the potential...

Published: 7/24/2026 | Inventor(s): Ranjan Perera

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics

Whole Genome Doubling as a Cancer Prognostic Marker

Value PropositionBroad Applicability: The technology effectively detects multiple different cancer types, including glioblastoma, melanoma, and adenocarcinoma. Simple Methodology: Not reliant on expensive instruments or technology. Most diagnostic labs already possess all the required materials and instruments. Earlier Detection: The technology can...

Published: 7/24/2026 | Inventor(s): Sergi Regot, Adler Guerrero Zuniga

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools

Antibodies that Enhance PAD4 Activity for the Study of Autoimmune Diseases

Value Proposition· Enhanced Research Capabilities: Provides five distinct human monoclonal antibodies that enhance PAD4 activity for in vitro and in vivo experimental assays, enabling researchers to study PAD4's function in autoimmune diseases such as rheumatoid arthritis.· Scalable Production: Utilizes commercially available immortalized...

Published: 7/24/2026 | Inventor(s): Felipe Andrade, Jing Shi, Antony Rosen, Erika Darrah

Keywords(s): Antibodies, Autoimmune Diseases, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Inflammatory Disorders, Monoclonal Antibodies, Research Reagent

Category(s): Clinical and Disease Specializations > Autoimmunity, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Antibodies

Clinical-grade in-home automatic human sleep measurement using artificial intelligence and a novel sensor array

Unmet Need Sleep is usually measured in a clinic utilizing a technique called Polysomnography (PSG). PSG’s efficacy is largely dependent on a trained technician to accurately place EEG/EOG/EMG sensors across the patient’s head at a sleep clinic and then accurately interrupt the signals by eye. The sleep clinic setting also introduces a suboptimal testing...

Published: 7/24/2026 | Inventor(s): Naresh Punjabi, William Coon

Keywords(s):

Category(s): Technology Classifications > Computers, Electronics & Software > Machine Learning, Technology Classifications > Computers, Electronics & Software > Sensors

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