Search Results - gregory+germino

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Pkd1 mouse models

We have introduced lox P sites into introns 2 and 4 of the mouse Pkdl gene which allows its regulated inactivation. Mutations in human PKD1 account for at-85% of all cases of human autosomal dominant polycystic kidney disease. We have shown that we can recapitulate a human-like disease presentation using inducible Cre-recombinases. This model is a powerful...

Published: 6/20/2024 | Inventor(s): Gregory Germino, Heiner Westphal, Klaus Piontek

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

PKD2 Neo Mouse Line (also called Pkd2cond mutant)

Conditional Mouse Model of Polycystic Kidney Disease (PKD2Cond)JHU REF: C11721Material available at Jackson Laboratory (www.jax.org)Stock No: 017292 - B6.129X1(Cg)-Pkd2tm1.1Tjwt/JInvention novelty: This tangible material is a transgenic mouse strain with a mutant Pkd2 (Polycystic Kidney Disease 2) gene. This Pkd2 conditional mouse model may be used...

Published: 6/20/2024 | Inventor(s): Gregory Germino, Terry Watnick

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

1. Pkd2(tm1Tjw) Mouse line 2. Pkd2(tm1.1Tjw) 3. Pkd2(tm1.2Tjw) 4. Pkd2(tm1.3Tjw) 5. Pkd2(tm1.4Tjw)

C11274: Mouse Model to study Human Autosomal Dominant Polycystic Kidney Disease.Value Proposition: Inventors disclose five mouse lines with loxP sites introduced into introns 10 and 13 of the mouse Pkd2 gene that allow its regulated inactivation using inducible Cre-recombinases. This mouse model can mimic the features of human autosomal dominant polycystic...

Published: 6/20/2024 | Inventor(s): Gregory Germino, Miguel Garcia-Gonzalez, Terry Watnick

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Pkd1(superscript ko) Mouse Line (Pkd1[superscript tm1Ggg]; it is also known as Pkd1[superscript beta-gal-null])

C10754: Mouse Model For Polycystic Kidney Disease Gene KnockoutNovelty: This technology is a mutant mice containing beta-galactosidase instead of Pkd1 gene to study the pathogenesis of autosomal dominant polycystic kidney disease.Value Proposition: Autosomal dominant polycystic kidney disease is characterized by cyst formation in the kidney and other...

Published: 6/20/2024 | Inventor(s): Klaus Piontek, Gregory Germino

Keywords(s): Basic Research Biomarker, Biomarker, Cell Lines, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, In Vivo Research Tool, Kidney Disorders, Knock Out Mouse Model, Mouse Cell Lines, Mouse Model, Polycystic Kidney Disease

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Nephrology > Polycystic Kidney Disease, Technology Classifications > Diagnostics > Biomarkers

Line 1: Pkhd1flox3-4 mouse line, formal name Pkhd1tm1Ggg.; Pkhd1del3-4 mouse line, formal name Pkhd1tm1Ggg.1

C04916: Line 1: Pkhd1flox3-4 mouse line, formal name Pkhd1tm1Ggg.; Pkhd1del3-4 mouse line, formal name Pkhd1tm1Ggg.1 Technical Details: Pkhd1flox3-4, when mutated, causes human autosomal recessive polycystic kidney disease (ARPKD). The Pkhdlde13-4 allele results after Cre-mediated deletion of exons 3 and 4. Homozygosity for this allele results in a...

Published: 6/20/2024 | Inventor(s): Junya Kaimori, Miguel Garcia-Gonzalez, Luis Menezes, Gregory Germino

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools