Search Results - large+animal+cell+lines

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ENGINEERED CELLS EXPRESSING PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) OR A MODIFIED FORM THEREOF AND RELATED METHODS

Unmet NeedProstate cancer is the second leading cause of cancer related death in American men and it is estimated that approximately 164,690 new cases will be diagnosed in 2018. Various treatment strategies, including surgery, radiation and chemotherapy, exist for prostate cancer but their success depends on the stage of the cancer at diagnosis. Novel...

Published: 3/14/2025 | Inventor(s): Martin Pomper, David Huss, Hyam Levitsky, Il Minn

Keywords(s): Biologics, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Large Animal Cell Lines, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Whole cell

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies

PS120/FLAG-NF2 Cells

Invention novelty: JHU researchers have generated PS120/FLAG-NF2 cells with human WTNHE3 expression (no TAG), stable human R799C mutant NHE3 expression (no tag), and with stable rabbit WT NHE3 expression (no tag). Value Proposition: NHE null fibroblasts expression in different species and polymorphisms of NHE3 to be used for functional studies. R799C...

Published: 3/13/2025 | Inventor(s): Mark Donowitz, Chung-Ming Tse

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Large Animal Cell Lines

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

hCNT3/PK15NTD

C04306: hCNT3/PK15NTD Technical Details: Cell line derived from swine kidney tubular epithelial cells which contains transfected human CNT3 as its only nucleoside transporter.Looking for Partners: Can be used to study the role of hCNT3 in modulation the physiological effects of nucleosides such as adenosine and the pharmacological effects of nucleoside...

Published: 3/13/2025 | Inventor(s): Chung-Ming Tse

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, In Vivo Research Tool, Large Animal Cell Lines, Large Animal Model, Large Animal Model Xenograft, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

hENT2/PK15NTD

C04258: hENT2/PK15NTD Technical Details: Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT2 as its only nucleoside transporter.Looking for Partners: Can be used to study the role of hENT2 in modulating the physiological effects of nucleosides such as adenosine and the pharmacological effects of nucleoside...

Published: 3/13/2025 | Inventor(s): Jeffrey Ward, Chung-Ming Tse

Keywords(s): Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Large Animal Cell Lines, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

hENT1/PK15NTD

C04257: hENT1/PK15NTD Technical Details: Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT1 as its only nucleoside transporter.Looking for Partners: Can be used to study the role of hENT1 in modulating the physiological effects of nucleosides such as adenosine and the pharmacological effects of nucleoside...

Published: 3/13/2025 | Inventor(s): Jeffrey Ward, Chung-Ming Tse

Keywords(s): Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Large Animal Cell Lines, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

PK15NTD Cells

C04252: PK15NTD Cells Technical Details: Cell line derived from swine kidney tubular epithelial cells which are deficient in endogenous nucleoside transporters.Looking for Partners: Pharmacological tool for evaluation of cytotoxicity of neucleoside analog drugs in mammalian systems.

Published: 3/13/2025 | Inventor(s): Jeffrey Ward, Chung-Ming Tse

Keywords(s): Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Large Animal Cell Lines, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

LuSIV Cells: A Highly Sensitive Detection System for Infectious HIV and Related Retroviruses

C03712: LuSIV Cells: A Highly Sensitive Detection System for Infectious HIV and Related Retroviruses Technical Details: JHU researchers constructed a reporter cell line, derived from human CEMx174 cells, that can be used to readily identify cells that are infected with HIV and related retroviruses. This cell line, designated LuSIV, contains a reporter...

Published: 3/13/2025 | Inventor(s): Jason Roos, James Hildreth, Maureen Maughan, Janice Clements

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, HIV, HIV/AIDS, Human Cell Lines, In Vitro Research Tool, Infectious Diseases, Large Animal Cell Lines, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools