Search Results - mark+donowitz

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Nanoparticle-NHE3 Peptide to Treat Diarrhea

Value Proposition:· Nanoparticle-based delivery of therapeutic that enhances intestinal sodium absorption · Broad clinical applications in severe diarrhea, whether acute or chronic· Effective treatment across heterogeneous presentations of diarrhea · Appropriate for patients of all ages Technology Description· Researchers...

Published: 3/14/2025 | Inventor(s): Mark Donowitz, Jordan Green, Nicholas Zachos, Hannah Vaughan

Keywords(s):

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology > Crohn's Disease, Clinical and Disease Specializations > Gastroenterology > Inflammatory Bowel Disease, Clinical and Disease Specializations > Gastroenterology > Ulcerative Colitis, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

PS120/FLAG-NF2 Cells

Invention novelty: JHU researchers have generated PS120/FLAG-NF2 cells with human WTNHE3 expression (no TAG), stable human R799C mutant NHE3 expression (no tag), and with stable rabbit WT NHE3 expression (no tag). Value Proposition: NHE null fibroblasts expression in different species and polymorphisms of NHE3 to be used for functional studies. R799C...

Published: 3/13/2025 | Inventor(s): Mark Donowitz, Chung-Ming Tse

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Large Animal Cell Lines

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Human Enteroids

Invention Novelty: This invention establishes human enteroids as nontransformed cell culture models to understand human intestinal physiology and pathophysiology and the epithelial response, including host restriction, cell type restriction, and virus-induced fluid secretion. Value Proposition: Johns Hopkins researchers have developed novel,...

Published: 3/13/2025 | Inventor(s): Mark Donowitz, Olga Kovbasnjuk, Nicholas Zachos

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Small Peptide Stimulator of NHE3, the Brush Border Epithelial Na/H Exchanger

C11498: Effective Treatment of Acute Diarrhea Using a Novel Peptide Modification Novelty: A peptide derived from the Sodium-Hydrogen Exchanger-3 (NHE-3) protein that increases sodium absorption in the intestine, aiding rehydration and can be used as a therapeutic for acute diarrhea. Value Proposition: The Center for Disease Control recommends...

Published: 3/13/2025 | Inventor(s): Randen Patterson, Damian Van Rossum, Nicholas Zachos, Mark Donowitz

Keywords(s): Acute Diarrhea, Basic Research Biomarker, Biologics, Cell Signaling, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Molecular Switches/Receptors, Peptide, Peptides, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Gastroenterology

Fibroblasts that are Null in NHES Stably Transfected with NHE1 or NHE2 or the Parent Line CCL39

C10183: Fibroblast Cell Line with Cloned Mammalian Na+/H+ ExchangersNovelty: A fibroblast cell line stably transfected by three isoforms of the Na+/H+ exchanger, NHE-1, NHE-2 and NHE-3, to assess Na+/H+ exchange function with null background.Value Proposition: Na+/H+ exchangers, NHEs, maintain the electrochemical gradient in mammalian cells by catalyzing...

Published: 3/13/2025 | Inventor(s): Chung-Ming Tse, Mark Donowitz

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Signaling, Discovery/Research Tools, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines