Search Results - damian+van+rossum

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Small Peptide Stimulator of NHE3, the Brush Border Epithelial Na/H Exchanger

C11498: Effective Treatment of Acute Diarrhea Using a Novel Peptide Modification Novelty: A peptide derived from the Sodium-Hydrogen Exchanger-3 (NHE-3) protein that increases sodium absorption in the intestine, aiding rehydration and can be used as a therapeutic for acute diarrhea. Value Proposition: The Center for Disease Control recommends...

Published: 3/13/2025 | Inventor(s): Randen Patterson, Damian Van Rossum, Nicholas Zachos, Mark Donowitz

Keywords(s): Acute Diarrhea, Basic Research Biomarker, Biologics, Cell Signaling, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Molecular Switches/Receptors, Peptide, Peptides, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Gastroenterology

Developing Anti-cancer Drugs by Blockade of IP6-HSP90 Binding

C05044: Developing Anti-cancer Drugs by Blockade of IP6-HSP90 BindingValue Proposition: A cellular enzyme known as inositol pyrophosphate 6 kinase 2 (IP6K2) has an important role in programmed cell death (apoptosis). JHU scientists discovered an interaction between IP6K2 and a protein known as Heat Shock Protein-90 (HSP90). Binding of IP6K2 with HSP90...

Published: 3/13/2025 | Inventor(s): Randen Patterson, Krishna Juluri, Katherine Sixt, Asif Mustafa, Damian Van Rossum, Anutosh Chakraborty, Michael Koldobskiy, Solomon Snyder

Keywords(s): Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mechanism of Action Biomarker, Non-novel, Predicted Novelty, Repurposed, Target-based Screening Tool, Therapeutic Matter, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Research Tools > Assays