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Developing Anti-cancer Drugs by Blockade of IP6-HSP90 Binding

C05044: Developing Anti-cancer Drugs by Blockade of IP6-HSP90 BindingValue Proposition: A cellular enzyme known as inositol pyrophosphate 6 kinase 2 (IP6K2) has an important role in programmed cell death (apoptosis). JHU scientists discovered an interaction between IP6K2 and a protein known as Heat Shock Protein-90 (HSP90). Binding of IP6K2 with HSP90...

Published: 10/3/2024 | Inventor(s): Randen Patterson, Krishna Juluri, Katherine Sixt, Asif Mustafa, Damian Van Rossum, Anutosh Chakraborty, Michael Koldobskiy, Solomon Snyder

Keywords(s): Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mechanism of Action Biomarker, Non-novel, Predicted Novelty, Repurposed, Target-based Screening Tool, Therapeutic Matter, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Research Tools > Assays