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Generation of Novel Prostate Cancer Cell Lines that Employ the Alternative Lengthening of Telomeres (ALT) Telomere Maintenance Mechanism

Unmet NeedInstead of telomerase, approximately 10% of cancers maintain telomeres via a DNA template dependent mechanism called Alternative Lengthening of Telomeres (ALT). The ALT pathway is dependent on homologous recombination and tightly linked to recurrent cancer-associated somatic inactivating mutations of ATRX or DAXX, genes encoding chromatin...

Published: 3/13/2025 | Inventor(s): Christopher Heaphy, Mindy Graham, Alan Meeker, Jacqueline Brosnan-Cashman, Michael Haffner, Anthony Rizzo

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools