Search Results - simon+williams

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A System to Enhance Understanding of the Intrinsic Activity of ProPSAJHU REF: [C12296]Invention novelty: This technology is a system to enhance understanding of the intrinsic proteolytic activity of ProPSA. Protein-specific antigen (PSA) is a protease secreted as a zymogen, ProPSA. Value Proposition: Variants of ProPSA are poorly understood. They...

Published: 3/13/2025 | Inventor(s): Simon Williams

Keywords(s): Antigens, Cell Signaling, Discovery/Research Tools, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Bcl-2 BH4 domain-induced gene expression profiles

Bcl-2 BH4 domain-induced gene expression profilesJHU ID: C12295Abstract:Bcl-2 is a validated target for cancer therapies. Current small molecule drug inhibitors mimic the BH3 domain of pro-apoptotic Bcl-2 family members, binding to a pocket composed mainly of Bcl-2 homology (BH) domains 1-3, and only partially BH4. Surprisingly, while these agents are...

Published: 3/13/2025 | Inventor(s): Simon Williams

Keywords(s): Antigens, Basic Research Biomarker, Cancers, Cell Lines, Cell Signaling, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Prostate Cancer, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology > Prostate Cancer

Targeting outer nuclear membrane Bcl-2

C12294: Transgenic Bcl2 Cells and ProPSA Panel for Prostate Cancer Drug DiscoveryNovelty: Recombinant proPSA panel and transgenic Bcl2 prostate cancer cell lines, enabling the detailed mechanistic analysis of prostate tumorigenesis and development of novel anti-cancer treatment strategies.Value Proposition: Due to the lack of early clinical manifestations...

Published: 3/13/2025 | Inventor(s): Simon Williams

Keywords(s): Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Prostate Cancer, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools