Search Results - stephen+meltzer

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A Device and Method to Treat Esophageal Disorders

Unmet needAn effective yet convenient method to treat esophageal disorders does not exist. For example, there is pressing need for non-invasive therapeutic options for patients with Barrett’s esophagus which progresses to low-grade dysplasia or high grade dysplasia. Technology OverviewJohns Hopkins researchers developed devices and methods to administer...

Published: 6/27/2024 | Inventor(s): Florin Selaru, Stephen Meltzer, George Coles, Honggang Cui

Keywords(s): Cancers, Disease Indication, Esophageal Cancer, Interventional and Surgical Systems

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ear, Nose & Throat, Clinical and Disease Specializations > Oncology > Esophageal Cancer, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

MicroRNA Profiling Reveals Dynamic Changes in the Expression of miR-31 During IBD-associated Neoplastic Transformation

TITLE: Novel MicroRNA Diagnostic for IBD-associated Colorectal CancerCASE NUMBER: C10775 UNMET NEEDChronic idiopathic inflammatory bowel disease (IBD) predisposes to the development of colorectal carcinoma. Current preventive measures to diminish colorectal cancer mortality in IBD patients consist of periodic surveillance colonoscopies with...

Published: 6/27/2024 | Inventor(s): Stephen Meltzer, Alexandru Olaru

Keywords(s): Basic Research Biomarker, Biomarker, Cancers, Chronic Inflammatory Diseases, Cloning Reagents, Colorectal Cancer, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Inflammatory Bowel Disease, Inflammatory Bowel Disease (IBD), Mechanism-of-action Biomarker, Nucleotide, Research Reagent, Therapeutic Matter, Therapeutics

BARH-like Gene 1 (BARX1) in Gastric Carcinogenesis

C11718: Novel Epigenetic Diagnostic Biomarker for Gastric CancerNovelty: A novel epigenetic biomarker for gastric cancer to enable earlier diagnosis and subsequent intervention.Value Proposition: Currently gastric cancer is diagnosed by tissue biopsies, which are invasive and can be inaccurate, often resulting in delayed diagnosis. This invention identified...

Published: 6/27/2024 | Inventor(s): Stephen Meltzer, Rachana Agarwal

Keywords(s): Biomarker, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gastric Cancer, In Vitro Diagnostics, In Vitro Research Tool, Prognostic Biomarker, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Gastric Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Prognostic Biomarkers

Novel DNA hypermethylation diagnostic biomarkers for colorectal cancer

C11173: Tissue -derived Hypermethylated DNA Diagnostic Biomarkers for Colorectal CancerValue Proposition: DNA methylation is a mechanism where methyl groups are added to strands of DNA at CpG islands and is thought to modify gene expression. DNA hypermethylation is a common epigenetic abnormality found in cancers and is emerging as a promising class...

Published: 6/27/2024 | Inventor(s): Clement Boland, Ajay Goel, Stephen Meltzer, Yuriko Mori

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

Diagnosis of Cancers from Normal Mucosal Specimens

C10435: Early Diagnosis of Esophageal Cancer in Morphologically Normal Tissue Samples Value Proposition: Esophageal adenocarcinoma (EAC) is a lethal disease with 5-year survival rates of only 10-20%. Worldwide, EAC is the 7th leading cause of cancer death. Barrett's esophagus (BE) is a precursor condition of EAC. Early detection is the best means to...

Published: 6/27/2024 | Inventor(s): Florin Selaru, Stephen Meltzer

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

Specific Delivery of a Tumor-ablating Agent by a DECApeptide to Colon and Esophageal Cancer Cell Lines as a Therapeutic Treatment

C10039: Specific Delivery of a Tumor-ablating Agent by a DECApeptide to Colon and Esophageal Cancer Cell Lines as a Therapeutic TreatmentValue Proposition: The effectiveness of immunotherapeutic antibodies is limited by their relatively large size. This attribute results in the antibody attachment being limited to the exposed areas of a solid tumor....

Published: 6/27/2024 | Inventor(s): Stephen Meltzer, John Abraham

Keywords(s): Biologics, Cancers, Colorectal Cancer, Disease Indication, Esophageal Cancer, Peptide, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ear, Nose & Throat, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Clinical and Disease Specializations > Oncology > Esophageal Cancer, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities