Search Results - stephen+meltzer

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A Device and Method to Treat Esophageal Disorders

Unmet needAn effective yet convenient method to treat esophageal disorders does not exist. For example, there is pressing need for non-invasive therapeutic options for patients with Barrett’s esophagus which progresses to low-grade dysplasia or high grade dysplasia. Technology OverviewJohns Hopkins researchers developed devices and methods to administer...

Published: 3/13/2025 | Inventor(s): Florin Selaru, Stephen Meltzer, George Coles, Honggang Cui

Keywords(s): Cancers, Disease Indication, Esophageal Cancer, Interventional and Surgical Systems

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ear, Nose & Throat, Clinical and Disease Specializations > Oncology > Esophageal Cancer, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

BARH-like Gene 1 (BARX1) in Gastric Carcinogenesis

C11718: Novel Epigenetic Diagnostic Biomarker for Gastric CancerNovelty: A novel epigenetic biomarker for gastric cancer to enable earlier diagnosis and subsequent intervention.Value Proposition: Currently gastric cancer is diagnosed by tissue biopsies, which are invasive and can be inaccurate, often resulting in delayed diagnosis. This invention identified...

Published: 3/13/2025 | Inventor(s): Stephen Meltzer, Rachana Agarwal

Keywords(s): Biomarker, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Gastric Cancer, In Vitro Diagnostics, In Vitro Research Tool, Prognostic Biomarker, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Gastric Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Prognostic Biomarkers

Novel DNA hypermethylation diagnostic biomarkers for colorectal cancer

C11173: Tissue -derived Hypermethylated DNA Diagnostic Biomarkers for Colorectal CancerValue Proposition: DNA methylation is a mechanism where methyl groups are added to strands of DNA at CpG islands and is thought to modify gene expression. DNA hypermethylation is a common epigenetic abnormality found in cancers and is emerging as a promising class...

Published: 3/13/2025 | Inventor(s): Clement Boland, Ajay Goel, Stephen Meltzer, Yuriko Mori

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Colorectal Cancer, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

Diagnosis of Cancers from Normal Mucosal Specimens

C10435: Early Diagnosis of Esophageal Cancer in Morphologically Normal Tissue Samples Value Proposition: Esophageal adenocarcinoma (EAC) is a lethal disease with 5-year survival rates of only 10-20%. Worldwide, EAC is the 7th leading cause of cancer death. Barrett's esophagus (BE) is a precursor condition of EAC. Early detection is the best means to...

Published: 3/13/2025 | Inventor(s): Florin Selaru, Stephen Meltzer

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

Specific Delivery of a Tumor-ablating Agent by a DECApeptide to Colon and Esophageal Cancer Cell Lines as a Therapeutic Treatment

C10039: Specific Delivery of a Tumor-ablating Agent by a DECApeptide to Colon and Esophageal Cancer Cell Lines as a Therapeutic TreatmentValue Proposition: The effectiveness of immunotherapeutic antibodies is limited by their relatively large size. This attribute results in the antibody attachment being limited to the exposed areas of a solid tumor....

Published: 3/13/2025 | Inventor(s): Stephen Meltzer, John Abraham

Keywords(s): Biologics, Cancers, Colorectal Cancer, Disease Indication, Esophageal Cancer, Peptide, Single, Small Molecules, Targeted Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ear, Nose & Throat, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Colorectal Cancer, Clinical and Disease Specializations > Oncology > Esophageal Cancer, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities