Search Results - lieping+chen

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B7-DC Knockout Mice

Detailed DescriptionThe Pdcd1lg2 gene encodes the costimulatory molecule PD-L2 which is expressed in dendritic cells (DCs). To establish the mouse line Stk 017515 - B6N.129(Cg)-Pdcd1lg2tm2Dmp/J which is deficient for PD-L2, a genomic fragment containing exon 2 of the programmed cell death 1 ligand 2 (Pdcd1lg2 which encodes PD-L2) gene, two of loxP sites...

Published: 3/14/2025 | Inventor(s): Drew Pardoll, Lieping Chen, Kevin Gorski, Haruo Tsuchiya, Tahiro Shin

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models

B7-DC Variants in the Stimulation of Immune Responses

Unmet NeedUnfortunately, many human tumor cells have evolved ways of deactivating the body’s immune system by expressing inhibitory signals (e.g., PD-L1, CTLA-4) on tumor cell surfaces. As a consequence, there is a pressing need for novel immunotherapies that would allow immune cells to bypass specific inhibitory signals on tumor cells and carry out...

Published: 3/13/2025 | Inventor(s): Lieping Chen

Keywords(s): Bacterial Infections, Biologics, Cancers, Disease Indication, Immunotherapy, Infectious Diseases, Peptide, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Inhibition of Transplantation Rejection By Suppressing HVEM

C05085: Inhibition of Transplantation Rejection By Suppressing HVEM Technical Details: Decoy lymphotoxin beta receptor (LT? has potent immune inhibitory activities, and thus represents a promising biologic for the treatment of inflammation, autoimmune diseases and graft-versus-host disease (GVHD). As this reagent interrupts multiple molecular interactions,...

Published: 3/13/2025 | Inventor(s): Koji Tamada, Lieping Chen

Keywords(s): Biomarker, Bone Marrow, Bone Marrow Transplant, Disease Indication, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Transplantation > Bone Marrow Transplant, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Transplantation