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B7-DC Knockout Mice

Detailed DescriptionThe Pdcd1lg2 gene encodes the costimulatory molecule PD-L2 which is expressed in dendritic cells (DCs). To establish the mouse line Stk 017515 - B6N.129(Cg)-Pdcd1lg2tm2Dmp/J which is deficient for PD-L2, a genomic fragment containing exon 2 of the programmed cell death 1 ligand 2 (Pdcd1lg2 which encodes PD-L2) gene, two of loxP sites...

Published: 6/27/2024 | Inventor(s): Drew Pardoll, Lieping Chen, Kevin Gorski, Haruo Tsuchiya, Tahiro Shin

Keywords(s): Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models