Search Results - duojia+pan

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Unmet NeedThe Hippo signaling pathway governs organ size, tissue homeostasis and regeneration, through its control of cellular proliferation, survival and apoptosis. Its dysregulation has been implicated in cancer, fibrosis, and cardiovascular disease. Research tools that improve our understanding of Hippo pathway function in healthy and disease states...

Published: 9/26/2024 | Inventor(s): Duojia Pan, Nailing Zhang

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models

Targeting YAP Activity in Combination with Immunomodulation to Alter Regulatory T Cell-mediated Immune Regulation in order to Treat Cancer

TITLE: INHIBITION OF YAP FOR BREAKING TUMOR IMMUNE TOLERANCECASE NUMBER: C13353UNMET NEEDRegulatory T cells (Tregs) play critical roles in maintaining self-tolerance and homeostasis by suppressing the activation and function of other immune cells. At the same time, the immune-dampening effects of Tregs can inhibit the development...

Published: 9/26/2024 | Inventor(s): Benjamin Park, Drew Pardoll, Duojia Pan, Joseph Barbi, Fan Pan

Keywords(s): Biomarker, Cancers, Disease Indication, Mechanism-of-action Biomarker, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

TRE-YAP Transgenic Mice

C11626: Transgenic Mice with the Oncoprotein YAPNovelty: Transgenic mice that can reversibly express the oncoprotein YAP (Yes-Associated Protein).Value Proposition: The oncoprotein YAP controls cell proliferation and apoptosis and has been shown to be overexpressed in different types of cancer. This invention is a transgenic mouse line that can selectively...

Published: 9/26/2024 | Inventor(s): Duojia Pan

Keywords(s): Basic Research Biomarker, Cancers, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology