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Targeting YAP Activity in Combination with Immunomodulation to Alter Regulatory T Cell-mediated Immune Regulation in order to Treat Cancer

TITLE: INHIBITION OF YAP FOR BREAKING TUMOR IMMUNE TOLERANCECASE NUMBER: C13353UNMET NEEDRegulatory T cells (Tregs) play critical roles in maintaining self-tolerance and homeostasis by suppressing the activation and function of other immune cells. At the same time, the immune-dampening effects of Tregs can inhibit the development...

Published: 3/13/2025 | Inventor(s): Benjamin Park, Drew Pardoll, Duojia Pan, Joseph Barbi, Fan Pan

Keywords(s): Biomarker, Cancers, Disease Indication, Mechanism-of-action Biomarker, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities