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Using CD29 as a Marker for Cell Identification in Single Cell Analysis

AbstractWith the advent of cancer immunology, mass cytometry has been increasingly employed to characterize the responses to cancer therapies and the tumor microenvironment (TME). One of its most notable applications is efficient multiplexing of samples into batches by dedicating a number of metal isotope channels to barcodes, enabling robust data acquisition...

Published: 3/14/2025 | Inventor(s): Won Jin Ho, Elizabeth Jaffee, Soren Charmsaz, Nicole Gross

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Workflow for Targeted Analysis of Image Mass Cytometry

Technology Description· Researchers at Johns Hopkins have developed a streamlined workflow for performing targeted imaging in image mass cytometry (IMC) with improved region of interest (ROI) selection. · This approach for ROI identification uses adjacent stained sections (e.g., H&E, PAS) with more prominent tissue features as a guide.· ROI...

Published: 3/14/2025 | Inventor(s): Pei-Hsun Wu, Denis Wirtz, Won Jin Ho

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Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Imaging

Targeting PTPN22 in Cancer Therapy

Unmet NeedTumor-infiltrating lymphocytes (TILs) such as B-cells, T-cells, and natural killers are gaining traction in anti-tumor immune responses. TILs involve the use of special immune cells called T-cells, otherwise known as lymphocytes, which protect the body from viral infections, fight cancer, and coordinate the activities of other cells during...

Published: 3/14/2025 | Inventor(s): Elizabeth Jaffee, Won Jin Ho, Soren Charmsaz

Keywords(s): Cancers, Combination, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Target, Targeted Therapy/Immunotherapy, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Research Tools > Animal Models