Search Results - philip+wong

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Targeted capture of custom nucleotide sequences for single-cell sequencing

Value Proposition· Implementation only requires simple modification of current capture beads.· Allows for targeting of custom sequences of interest that may be cell-type specific or expressed at low levels.· Targets RNA molecules without polyA tails.· Inexpensive modification to existing commercial methods. Technology DescriptionResearchers...

Published: 3/14/2025 | Inventor(s): Jonathan Ling, Katherine Irwin, Irika Sinha, Philip Wong, Linda Orzolek, Tyler Creamer

Keywords(s):

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Assays

Identification of TDP-43 Cryptic Exons as Functional Fluid Biomarkers for Alzheimer's Disease and Related Dementia

JHU C16735Unmet Need: TDP-43 (Tar DNA-binding protein 43) acts as a guardian of the transcriptome by repressing the splicing of non-conserved, unannotated cryptic exons. Loss of TDP-43 function causes neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Limbic-Predominant Age-Related TDP-43 Encephalopathy...

Published: 3/14/2025 | Inventor(s): Philip Wong, Jonathan Ling

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Proteins, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Dementia

Target Validation of Splicing Repression, a Major Function of TDP-43 in the Motor Neuron

Unmet NeedAmyotrophic lateral sclerosis (ALS) is a rare but debilitating disease characterized by the death of motor neurons that eventually leads to difficulty moving, speaking, swallowing, and breathing. The fundamental cause of ALS is unknown and as a result treatment options are primarily restricted to physical therapy to help prolong muscle strength....

Published: 3/14/2025 | Inventor(s): Philip Wong, Aneesh Donde, Jonathan Ling, Liam Chen, Mingkuan Sun

Keywords(s): Amyotrophic Lateral Sclerosis, CNS and Neurological Disorders, Disease Indication, Target, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis, Technology Classifications > Therapeutic Modalities > Targets

Conditional Tau Mouse Lines that Faithfully Recapitulate Alzheimer’s Disease-like Pathologies

Value Proposition: Effective therapy for Alzheimer’s disease (AD), the most common form of dementia and a devastating illness for the elderly, remains a great unmet need. For translational research and preclinical drug development, animal models that faithfully mimic the cardinal pathological features of AD are critical. A major limitation of current...

Published: 3/13/2025 | Inventor(s): Philip Wong, Donald Price, Tong Li

Keywords(s): Alzheimer's Disease, Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

TDP-43 Suppression of Non-conserved Cryptic Exons is Compromised in Human Neurodegenerative Diseases

C13621: Suppression of Non-conserved Cryptic Exons is Compromised in Human Neurodegenerative DiseasesAbstractA novel mechanism underlying the suppression of non conserved cryptic exons. This mechanism is essential to maintain intron integrity, and is compromised in ALS-FTD, indicating that loss of function underlies pathogenesis of disease. Publication...

Published: 3/13/2025 | Inventor(s): Philip Wong, Jonathan Ling

Keywords(s): Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Basic Research Biomarker, CNS and Neurological Disorders, Dementia, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis, Clinical and Disease Specializations > Neurology > Dementia

Germline and Conditional Deletion of Tardbp

C11168: A Gene Linked to Obesity, and Alters Body Fat Metabolism Value Proposition: • Identifies novel therapeutic target to control obesity and diabetes. • Helps to understand incurable diseases: frontal temporal dementia and amyotrophic lateral sclerosis. Technical Details: JHU scientists have developed conditional knockout mice...

Published: 3/13/2025 | Inventor(s): Donald Price, Po-Min Chiang, Philip Wong

Keywords(s): Amyotrophic Lateral Sclerosis, Basic Research Biomarker, Biomarker, Cell Model, Clinical Diagnostics, CNS and Neurological Disorders, Dementia, Diabetes, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, In Vivo Research Tool, Knock Out Mouse Model, Mechanism-of-action Biomarker, Metabolic Disorders, Mouse Model, Neurodegeneration, Obesity, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Metabolic Diseases, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Clinical and Disease Specializations > Neurology > Amyotrophic Lateral Sclerosis, Clinical and Disease Specializations > Neurology > Dementia, Clinical and Disease Specializations > Neurology > Neurodegeneration, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Stem Cells

Nicastrin Knockout Mice: A Model for Human Head and Neck Squamous Cell Carcinoma

C10173: Mouse Model of Human Head and Neck Squamous Cell Carcinoma Technical Details: Cancers of the head and neck, the majority of which arise in the squamous cells that line the mucosal surfaces in the head and neck, account for 3% of all malignancies in the United States. Human head and neck squamous cell carcinoma is a clinically aggressive tumor,...

Published: 3/13/2025 | Inventor(s): Donald Price, Tong Li, Philip Wong

Keywords(s): Basic Research Biomarker, Cancers, Discovery/Research Tools, Disease Indication, Head & Neck Cancer, Head and Neck Cancer, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ear, Nose & Throat, Clinical and Disease Specializations > Oncology > Head & Neck Cancer, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

BACE2 Knockout Mice

C04556: BACE2 Knockout Mice Technical Details: Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta peptides. To examine the physiological roles of BACE2 and to determine whether BACE2 is the major beta-secretase in neurons, Johns Hopkins University researchers have created mice with targeted inactivation...

Published: 3/13/2025 | Inventor(s): Jonathan Yu, Donald Price, Philip Wong

Keywords(s): Alzheimer's Disease, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Neurodegeneration, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Beta-Secretase (BACE1) Polyclonal Antisera

C03929: Beta-Secretase (BACE1) Polyclonal Antisera Technical Details: To facilitate our understanding of the physiological role of BACE1 and its involvement in the generation of the Alzheimer?s disease (AD) Ab peptides, we generated a rabbit polyclonal antibody against BACE1. Our BACE1 antisera will be useful in the BACE1 levels and expression patterns...

Published: 3/13/2025 | Inventor(s): Huaibin Cai, Donald Price, Philip Wong

Keywords(s): Alzheimer's Disease, Antibodies, Biologics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Geriatric Conditions, Neurodegeneration, Proteomics/Immunoassays, Proteomics/Immunoassays Antiserum, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Beta-Secretase (BACE1) Knockout Fibroblast Cells

C03882: Beta-Secretase (BACE1) Knockout Fibroblast Cells Technical Details: We have developed BACE1 knockout cells to further facilitate our understanding of physiological consequences of the lack of BACE1 in cells. We have established BACE1 knockout immortalized cell lines by transforming the primary fibroblasts derived from BACE1 knockout mice. Looking...

Published: 3/13/2025 | Inventor(s): Donald Price, Huaibin Cai, Philip Wong

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

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