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BACE2 Knockout Mice

C04556: BACE2 Knockout Mice Technical Details: Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta peptides. To examine the physiological roles of BACE2 and to determine whether BACE2 is the major beta-secretase in neurons, Johns Hopkins University researchers have created mice with targeted inactivation...

Published: 6/26/2025 | Inventor(s): Jonathan Yu, Donald Price, Philip Wong

Keywords(s): Alzheimer's Disease, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model, Neurodegeneration, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools