Search Results - rat+model

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An ex vivo Model for Rapid Evaluation of Choroidal Mast Cell Degranulation

Unmet NeedAlmost 11 million people in the United States have symptoms of age-related macular degeneration (AMD). AMD is a multifactorial disease distinguished by progressive degeneration in the macular region of the eye, resulting in irreversible central vision loss among the elderly population. Current evidence suggests that inflammation plays a vital...

Published: 3/14/2025 | Inventor(s): Gerard Lutty, Shuntaro Ogura

Keywords(s): Discovery/Research Tools, Disease Indication, Eye Disorders, In Vitro Research Tool, In Vivo Research Tool, Macular Degeneration, Rat Model, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Assays, Clinical and Disease Specializations > Ophthalmology > Macular Degeneration, Clinical and Disease Specializations > Ophthalmology > Dry Age-Related Macular Degeneration

C09320 - Anti-mouse CD23 monoclonal antibody B3B4

Value Proposition: B3B4 is highly specific for murine B lineage cells - it did not significantly react with FcR on macrophages and T cells and, in addition, did not react with the high affinity mast cell FcR. B3B4 completely blocked IgE resetting, and a reciprocal inhibition of binding was seen in a dose-dependent fashion between IgE and B3B4, indicating...

Published: 3/13/2025 | Inventor(s): Daniel Conrad

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Proteomics/Immunoassays, Proteomics/Immunoassays Antibodies, Rat Model, Rat Model Xenograft, Research Reagent

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools