Search Results - huilin+yang

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Detection of Prostate Cancer Proteins in Serum for Cancer Diagnosis with a Blood Test

There is a crucial need of discovering novel biomarkers in addition to prostate specific antigen (PSA) to improve the specificity of clinical diagnosis for prostate cancer. This invention addresses this problem by discovering proteins from prostate cancer tissues that can be detected in patients’ blood. Hence, a blood test can be developed for detecting...

Published: 9/26/2024 | Inventor(s): Yan Li, Daniel Chan, Zhen Zhang, Lori Sokoll, Hui Zhang

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Prostate Cancer

Computational Head Model with Orbit (CHMO) Simulating Optic Nerve Injury Under Blunt Impact

Computational Head Model with Orbit (CHMO) Simulating Optic Nerve Injury Under Blunt Impact Case ID:C16069Disclosure Date:1/9/2020 Unmet need The Mayo Clinic estimates that over 200,000 traumatic brain injuries (TBIs) occur in the United States every year, usually as consequences of car accidents and contact sports. TBIs are associated with a variety...

Published: 9/27/2024 | Inventor(s): Nitin Daphalapurkar, Eric Singman, Timothy McCulley, Yang Li

Keywords(s):

Category(s): Clinical and Disease Specializations > Traumatic Injury, Clinical and Disease Specializations > Ophthalmology > Optic Neuropathy, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Computers, Electronics & Software > Artificial Intelligence

Single-chain Knobs-in-holes Bispecific Antibody Construction

Unmet Need: In the United States, 40% of males and 38% of females will develop cancer in their lifetimes. Additionally, as of 2015, the annual direct medical costs of cancer stood at $80.2 billion. Targeted therapies, such as monoclonal antibody drugs, show great promise in cancer treatment, but these therapies still have many important limitations...

Published: 9/27/2024 | Inventor(s): Jamie Spangler, Denis Wirtz, Huilin Yang, Wentao Wang, Michelle Karl

Keywords(s): Antibodies, Discovery/Research Tools, Monoclonal Antibodies, Research Reagent, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Technology Classifications > Research Tools > Research Antibodies

Engineered Bispecific Antibodies for Targeted Inhibition of Tumor Metastasis

Description: Unmet Need. In the United States, 40% of males and 38% of females will develop cancer in their lifetimes. Many types of cancers, including triple negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC), have devastatingly low five year survival rates, even after the removal of primary tumors. Poor prognoses for these cancer...

Published: 9/27/2024 | Inventor(s): Jamie Spangler, Denis Wirtz, Huilin Yang, Wentao Wang, Michelle Karl

Keywords(s): Target, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Antibodies, Clinical and Disease Specializations > Oncology

Ratiometric Sensor Response for Analyte Identification and Quantification

Unmet NeedGas detection is necessary for the well-being of people and the environment in order to identify potentially harmful gases in the air. Technology has developed recently where active micro gas sensors are becoming smaller, lower cost, more efficient, and more accurate to allow for more applications in the chemical process, automobiles, life...

Published: 9/26/2024 | Inventor(s): Howard Katz, Hui Li

Keywords(s): Environmental Sensing, Imaging and Sensing Systems, Sensors

Category(s): Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Energy, Infrastructure & Environment

Sensor with Interferent Vapor Referencing

Unmet NeedContinuous monitoring of harmful gases and vapors is the best form of preventive care against air hazards. Residential areas, commercial buildings, schools, and healthcare facilities are required to have such systems in place in case dangerous air pollutants are introduced. Air quality in medical facilities is especially important: poor air...

Published: 9/26/2024 | Inventor(s): Howard Katz, Yingli Chu, Hui Li, Tushita Mukhopadhyaya, Justine Wagner, Huidong Fan

Keywords(s): Environmental Sensing, Imaging and Sensing Systems, Sensors

Category(s): Technology Classifications > Industrial Tech > Energy, Infrastructure & Environment, Technology Classifications > Computers, Electronics & Software > Sensors, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Energy, Infrastructure & Environment

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

Improved Treatment Prognosis For CancersJHU REF: C12842Invention Novelty:This technology offers a prognostic panel derived from the gene expression of several different cancers, which was validated in multiple primary human samples. The panel, termed "AIM", differentiates patients into two tiers that correspond to a set of suggested treatment...

Published: 9/26/2024 | Inventor(s): Cynthia Zahnow, Stephen Baylin, Angela Guzzetta, Katherine Chiappinelli, Huili Li, Nita Ahuja

Keywords(s): Antagonists/Inhibitors, Biomarker, Cancers, Clinical Diagnostics, Combination, Disease Indication, Epithelial Cancer, In Vitro Diagnostics, Non-novel, Pharmakodynamic Biomarker, Predicted Novelty, Repurposed, Small Molecules, Targeted Therapy/Immunotherapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Epithelial Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Targeting Collagen Strands for Imaging and Therapy

C11749: Novel Collagen Targeting for Imaging and Therapeutic ApplicationsNovelty: This technology employs collagen mimetic peptides to target denatured collagen in vivo for imaging and treatment of cancer and other diseases affecting the collagen matrix.Value Proposition: There are currently no available means of targeting a denatured collagen matrix...

Published: 9/26/2024 | Inventor(s): Yang Li, Catherine Foss, Allen Yi-Lan Wang, Martin Pomper, Daniel Summerfield, Michael Yu

Keywords(s): Biologics, Cancers, Cardiovascular Diseases, Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Peptide, Radioisotope Therapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities

A p105-based NF-(kappa) B Super repressor

C04290: A p105-based NF-(kappa) B Super repressor Technical Details: Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is latent, and is activated transiently by stimuli and stresses. However, under pathological...

Published: 9/26/2024 | Inventor(s): Li Lin

Keywords(s): Biologics, Cancers, Chemotherapy, Disease Indication, Nucleic Acid, Single, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities