Search Results - cynthia+zahnow

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Combination Treatment Using DNA Demethylating Agents and Inhibitors of Polyamine Biosynthesis to Enhance Antitumor Response

Unmet NeedThe present invention could be used for treatment of any solid tumor, including ovarian, breast, melanoma, lung, colon, pancreas, liver, esophageal, stomach, epithelial, sarcoma, cervical, and uterine. This encompasses a huge market size and compelling unmet need. The effectiveness of this combination therapy has been demonstrated specifically...

Published: 6/27/2024 | Inventor(s): Cynthia Zahnow, Robert Casero, Meghan Travers

Keywords(s): Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities

Compositions and Methods for Treating Solid Tumors

UNMET NEEDCancers are now recognized as being driven by widespread changes in the epigenome including changes in DNA methylation and chromatin packaging. Changes in DNA methylation include global loss of methylation and focal gain of methylation at promoter regions of tumor suppressor genes leading to transcriptional silencing. DNA methylation, the...

Published: 6/27/2024 | Inventor(s): Cynthia Zahnow, Stephen Baylin, Michael Topper, Meredith Stone

Keywords(s): Cancers, Chemotherapy/Chemotherapy, Combination, Disease Indication, Therapeutic Matter, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

Improved Treatment Prognosis For CancersJHU REF: C12842Invention Novelty:This technology offers a prognostic panel derived from the gene expression of several different cancers, which was validated in multiple primary human samples. The panel, termed "AIM", differentiates patients into two tiers that correspond to a set of suggested treatment...

Published: 6/27/2024 | Inventor(s): Cynthia Zahnow, Stephen Baylin, Angela Guzzetta, Katherine Chiappinelli, Huili Li, Nita Ahuja

Keywords(s): Antagonists/Inhibitors, Biomarker, Cancers, Clinical Diagnostics, Combination, Disease Indication, Epithelial Cancer, In Vitro Diagnostics, Non-novel, Pharmakodynamic Biomarker, Predicted Novelty, Repurposed, Small Molecules, Targeted Therapy/Immunotherapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Epithelial Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities